BFR1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BFR1_SCHPO
• UniProt AC: P41820
• Protein Name: Brefeldin A resistance protein
• Gene Name: bfr1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1530
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Confers hyper-resistance to brefeldin A (BFA), an inhibitor of intracellular protein transport. Could serve as an efflux pump of various antibiotics..
• Protein Sequence: MNQNSDTTHGQALGSTLNHTTEVTRISNSSDHFEDSSSNVDESLDSSNPSSNEKASHTNEEYRSKGNQSYVPSSSNEPSPESSSNSDSSSSDDSSVDRLAGDPFELGENFNLKHYLRAYKDSLQRDDIITRSSGVCMRDHSVYGVGSGYEFLKTFPDIFLQPYRAITEKQVVEKAILSHCHALANAGELVMVLGQPGSGCSTFLRSVTSDTVHYKRVEGTTHYDGIDKADMKKFFPGDLLYSGENDVHFPSLTTAETLDFAAKCRTPNNRPCNLTRQEYVSRERHLIATAFGLTHTFNTKVGNDFVRGVSGGERKRVTISEGFATRPTIACWDNSTRGLDSSTAFEFVNVLRTCANELKMTSFVTAYQASEKIYKLFDRICVLYAGRQIYYGPADKAKQYFLDMGFDCHPRETTPDFLTAISDPKARFPRKGFENRVPRTPDEFEQMWRNSSVYADLMAEMESYDKRWTETTPASSEAPEKDNFGSDISATTKHELYRQSAVAEKSKRVKDTSPYTVTFSQQLWYCLARSWERYINDPAYIGSMAFAFLFQSLIIGSIFYDMKLNTVDVFSRGGVLFFSILFCALQSLSEIANMFSQRPIIAKHRASALYHPAADVISSLIVDLPFRFINISVFSIVLYFLTNLKRTAGGFWTYFLFLFIGATCMSAFFRSLAGIMPNVESASALGGIGVLAIAIYTGYAIPNIDVGWWFRWIAYLDPLQFGFESLMINEFKARQFECSQLIPYGSGYDNYPVANKICPVTSAEPGTDYVDGSTYLYISFNYKTRQLWRNLAIIIGYYAFLVFVNIVASETLNFNDLKGEYLVFRRGHAPDAVKAAVNEGGKPLDLETGQDTQGGDVVKESPDNEEELNKEYEGIEKGHDIFSWRNLNYDIQIKGEHRRLLNGVQGFVVPGKLTALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNGRGLDSTFQRRTGYVQQQDVHIGESTVREALRFSAALRQPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPGSGLNVEQRKRATIGVELAAKPALLLFLDEPTSGLDSQSAWSIVCFLRKLADAGQAILCTIHQPSAVLFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYILDVIGAGATATTNRDWHEVWNNSEERKAISAELDKINASFSNSEDKKTLSKEDRSTYAMPLWFQVKMVMTRNFQSYWREPSILMSKLALDIFAGLFIGFTFYNQGLGVQNIQNKLFAVFMATVLAVPLINGLQPKFIELRNVFEVREKPSNIYSWVAFVFSAIIVEIPFNLVFGTLFFLCWFYPIKFYKHIHHPGDKTGYAWLLYMFFQMYFSTFGQAVASACPNAQTASVVNSLLFTFVITFNGVLQPNSNLVGFWHWMHSLTPFTYLIEGLLSDLVHGLPVECKSHEMLTINPPSGQTCGEYMSAFLTNNTAAGNLLNPNATTSCSYCPYQTADQFLERFSMRYTHRWRNLGIFVGYVFFNIFAVLLLFYVFRVMKLRSTWLGKKITGTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	THGQALGSTLNHTTE CCHHHHHHHCCCCCE	30.48	29996109
16	Phosphorylation	HGQALGSTLNHTTEV CHHHHHHHCCCCCEE	29.76	29996109
27	Phosphorylation	TTEVTRISNSSDHFE CCEEEEECCCCCCCC	27.63	29996109
28	N-linked_Glycosylation	TEVTRISNSSDHFED CEEEEECCCCCCCCC	43.06	-
29	Phosphorylation	EVTRISNSSDHFEDS EEEEECCCCCCCCCC	30.28	29996109
30	Phosphorylation	VTRISNSSDHFEDSS EEEECCCCCCCCCCC	39.08	25720772
36	Phosphorylation	SSDHFEDSSSNVDES CCCCCCCCCCCCCHH	28.59	25720772
37	Phosphorylation	SDHFEDSSSNVDESL CCCCCCCCCCCCHHH	37.95	29996109
38	Phosphorylation	DHFEDSSSNVDESLD CCCCCCCCCCCHHHH	44.84	29996109
43	Phosphorylation	SSSNVDESLDSSNPS CCCCCCHHHHCCCCC	32.77	29996109
47	Phosphorylation	VDESLDSSNPSSNEK CCHHHHCCCCCCCCC	53.04	29996109
56	Phosphorylation	PSSNEKASHTNEEYR CCCCCCCCCCCHHHH	41.74	24763107
58	Phosphorylation	SNEKASHTNEEYRSK CCCCCCCCCHHHHHC	41.66	21712547
64	Phosphorylation	HTNEEYRSKGNQSYV CCCHHHHHCCCCCCC	43.97	21712547
67	N-linked_Glycosylation	EEYRSKGNQSYVPSS HHHHHCCCCCCCCCC	31.21	-
95	Phosphorylation	SSSSDDSSVDRLAGD CCCCCCCHHHHHCCC	34.72	27738172
273	N-linked_Glycosylation	TPNNRPCNLTRQEYV CCCCCCCCCCHHHHH	47.32	-
334	N-linked_Glycosylation	PTIACWDNSTRGLDS CEEEEECCCCCCCCH	22.30	-
450	N-linked_Glycosylation	EFEQMWRNSSVYADL HHHHHHHCCHHHHHH	24.11	-
469	Phosphorylation	ESYDKRWTETTPASS HHHHCCCCCCCCCCC	27.73	21712547
471	Phosphorylation	YDKRWTETTPASSEA HHCCCCCCCCCCCCC	30.61	21712547
472	Phosphorylation	DKRWTETTPASSEAP HCCCCCCCCCCCCCC	15.60	24763107
475	Phosphorylation	WTETTPASSEAPEKD CCCCCCCCCCCCCCC	29.89	24763107
476	Phosphorylation	TETTPASSEAPEKDN CCCCCCCCCCCCCCC	39.62	24763107
486	Phosphorylation	PEKDNFGSDISATTK CCCCCCCCCCCHHHH	27.86	28889911
489	Phosphorylation	DNFGSDISATTKHEL CCCCCCCCHHHHHHH	25.26	28889911
491	Phosphorylation	FGSDISATTKHELYR CCCCCCHHHHHHHHH	29.59	28889911
492	Phosphorylation	GSDISATTKHELYRQ CCCCCHHHHHHHHHH	30.07	25720772
500	Phosphorylation	KHELYRQSAVAEKSK HHHHHHHHHHHHHCC	18.73	28889911
861	Phosphorylation	GGDVVKESPDNEEEL CCCCCCCCCCCHHHH	31.66	21712547
1159	N-linked_Glycosylation	RDWHEVWNNSEERKA CCHHHHHCCHHHHHH	47.53	-
1175	N-linked_Glycosylation	SAELDKINASFSNSE HHHHHHHHHHCCCCC	34.96	-
1179	Phosphorylation	DKINASFSNSEDKKT HHHHHHCCCCCCCCC	36.63	21712547
1186	Phosphorylation	SNSEDKKTLSKEDRS CCCCCCCCCCHHHHH	41.84	28889911
1188	Phosphorylation	SEDKKTLSKEDRSTY CCCCCCCCHHHHHHC	38.95	21712547
1449	N-linked_Glycosylation	YMSAFLTNNTAAGNL HHHHHHCCCCCCCCC	46.10	-
1460	N-linked_Glycosylation	AGNLLNPNATTSCSY CCCCCCCCCCCCCCC	49.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BFR1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BFR1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BFR1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MFS1_SCHPO	mfs1	genetic	22840777
YN43_SCHPO	mfs3	genetic	22840777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486; SER-489; THR-491AND THR-1186, AND MASS SPECTROMETRY.
PubMed: 18257517