NMT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMT1_SCHPO
• UniProt AC: P36597
• Protein Name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase {ECO:0000250|UniProtKB:P43534}
• Gene Name: nmt1 {ECO:0000303|PubMed:2358444}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 346
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme..
• Protein Sequence: MSTNKITFLTNWEATPYHLPIFLAQTRGYYEREGIEVAILEPTNPSDVTALIGSGKVDMGLKAMIHTLAAKARGYPVTSFGSLLNEPFTGLITLKGNGINDFKDIKGKRIGYVGEFGKIQLDDLCSKFGLSPSDYTAIRCGMNIAPAIINGEIDGGIGIECMQQVELERWCVSQGRPRSDVQMLRIDRLANLGCCCFCTILYIAHDEFIAKHPDKIKAFLRAIHSATLDMLKDPVQTYKEYIHFKREMGSELHREQFERCFAYFSHDISNVPRDWNKVTNYSKRLGIIPQDFEPNCTNGYLTWELDPDEKDPMGKQEAIAEIQDEIKQKGGVFSGNSLRYVEPANL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	EVAILEPTNPSDVTA EEEEECCCCHHHHHE		29996109
46	Phosphorylation	ILEPTNPSDVTALIG EECCCCHHHHHEEEC		29996109
49	Phosphorylation	PTNPSDVTALIGSGK CCCHHHHHEEECCCC		29996109
62	N6-(pyridoxal phosphate)lysine	GKVDMGLKAMIHTLA CCCCHHHHHHHHHHH		-
62	Other	GKVDMGLKAMIHTLA CCCCHHHHHHHHHHH		-
126	Phosphorylation	IQLDDLCSKFGLSPS EEHHHHHHHCCCCHH		25720772
131	Phosphorylation	LCSKFGLSPSDYTAI HHHHCCCCHHHHHHH		29996109
133	Phosphorylation	SKFGLSPSDYTAIRC HHCCCCHHHHHHHCC		25720772
179	Phosphorylation	VSQGRPRSDVQMLRI HHCCCCCHHCCHHHH		25720772
237	Phosphorylation	MLKDPVQTYKEYIHF HHCCHHHHHHHHHHH		25720772
238	Phosphorylation	LKDPVQTYKEYIHFK HCCHHHHHHHHHHHH		25720772
334	Phosphorylation	KQKGGVFSGNSLRYV HHHCCCCCCCCCEEE		24763107
337	Phosphorylation	GGVFSGNSLRYVEPA CCCCCCCCCEEEECC		29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMT1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMT1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of NMT1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.