dbPTM

MPH1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPH1_SCHPO
UniProt AC	Q9UT23
Protein Name	ATP-dependent DNA helicase fml1 {ECO:0000305}
Gene Name	fml1 {ECO:0000303\|PubMed:18851838}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	834
Subcellular Localization	Cytoplasm . Nucleus, nucleolus .
Protein Description	ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. [PubMed: 18851838]
Protein Sequence	MSDDSFSSDEDWDELDTQVVDKIENEYHNNTIGLNGYSVDEYFDANDSNRYRLQHELDESAAQQWVYPINVSFRDYQFNIVQKALFENVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTKPLVTQQMEACYKITGIPKSQTAELSGHVPVTTRNQYYQSRNVFFVTPQTILNDIKHGICDRTRISCLVIDEAHRSTGNYAYVEVVHLLSLSNKNFRILALSATPGNKLEAIQNVIDSLHISRIEIRTENSIDISQYVQKKEVDFFPVDLSAEITDIRDRFSSILEPMLQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNFPANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKLREVEEECFVGRSGYKKRIINHENYRPLMDDIEILLRDQSFVGHPKLEHLERIVTEYFEKEQTKDTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVRKAAGMSQKLQNETVKQFQKGEVNTLIATSIGEEGLDIGEVDMIICYDASASPIRMLQRMGRTGRKRKGYIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEKFRPVCDKRVIEIPKENEEVVVAPKKVQLRTKIKKKFFMPENALNGFITASALGKPKRALAKSEESPFEICPVTYSIEQEKKLEKYKRVCLRGLDIHRNRRLSQLSVTGRIPHSLATKSIHSFLKHLNTIDSQKAQEWRREINNQFQVSNINSTDRDTKQPKMHDFRQPLHPNPMTTLKRKGQHNSFSYDKSTLFYDNNNNLEEDLPDVNISISSRNEEASKTKPFDDRQQRLQQLVEKRKRMKGMLI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
689	Phosphorylation	IHRNRRLSQLSVTGR CCCCCCCHHCCCCCC		25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MPH1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MPH1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPH1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD26_SCHPO	rad26	genetic	18818364
EME1_SCHPO	eme1	genetic	18818364
CSN1_SCHPO	csn1	genetic	18818364
ASK1_SCHPO	ask1	genetic	18818364
PDP1_SCHPO	pdp1	genetic	18818364
RHP9_SCHPO	crb2	genetic	18818364
CLR4_SCHPO	clr4	genetic	18818364
RAD14_SCHPO	rhp14	genetic	18818364
RIK1_SCHPO	rik1	genetic	18818364
2AD1_SCHPO	par1	genetic	18818364
RAF1_SCHPO	raf1	genetic	18818364
RAF2_SCHPO	raf2	genetic	18818364
RL1DA_SCHPO	SPCC306.07c	genetic	18818364
SPO11_SCHPO	rec12	genetic	22723423
CSN3_SCHPO	csn3	genetic	22681890
YCX5_SCHPO	dbl1	genetic	22681890
YLZ1_SCHPO	SPAC750.01	genetic	22681890
SIR2_SCHPO	sir2	genetic	22681890
MGR2_SCHPO	mgr2	genetic	22681890
RAD1_SCHPO	rad1	genetic	22681890
ADDH_SCHPO	SPBC1289.14	genetic	22681890
YA07_SCHPO	SPAC5H10.07	genetic	22681890
OYEA_SCHPO	SPAC5H10.04	genetic	22681890
ZRG17_SCHPO	zrg17	genetic	22681890
PPR8_SCHPO	ppr8	genetic	22681890
YJB1_SCHPO	dbl2	genetic	22681890
YB22_SCHPO	SPBC31F10.02	genetic	22681890
ATP5E_SCHPO	atp15	genetic	22681890
HUS1_SCHPO	hus1	genetic	22681890
RENT1_SCHPO	upf1	genetic	22681890
RHP9_SCHPO	crb2	genetic	22681890
YA32_SCHPO	SPAC18B11.02c	genetic	22681890
CLR1_SCHPO	clr1	genetic	22681890
MHF2_SCHPO	mhf2	physical	24026537
MHF1_SCHPO	mhf1	physical	24026537
RAD5_SCHPO	rad8	genetic	24875629

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPH1_SCHPO

Related Literatures of Post-Translational Modification