TAZ1_SCHPO - dbPTM
TAZ1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAZ1_SCHPO
UniProt AC P79005
Protein Name Telomere length regulator taz1
Gene Name taz1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 663
Subcellular Localization Cytoplasm. Nucleus. Chromosome, telomere.
Protein Description Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis..
Protein Sequence MISVQSTETIQKVLENEGDQQFDKEVVQNSDSNIETGQISDSLTKAVEERAETESSSNLSNFTTSESESSKPAYCFNSHSQNMAEGSISIPVISHSMNVENEVSTAEGQDSRTGESENDQNAMIVRSIWDIEKASLLVNDCQNIANMAEQKVMMVSAIFSESSKDIVNPESFSERLGKETVKDLYEFNEQLTTKYGLEFRTIFFSYIRKYDAYWCLFEDLEKPLKSIQFFTGLIDLLDNTNKHLTLRSIVLDALLSADEEDSFYGDALVLFEELVIRYFGTDSNPSIDASEFILSCLPYTSLDALNVVCGQVWKSQKICDFLKSTIGNTSNSPLQLRASFPAFVNAVIHFLLEFKNVRRLERKDLSVKGMLYDSDSQQILNRLRERVSGSTAQSADEASGHESDASEDTFSERTLGLNSIDNTEISEVVSLGLVSSALDKITGLLSADNLSETVSQARDFSHTLSKSLKSRAKSLSQKEAANRSKLIAKRGDNLRREASLSSEQDDLSEDFPPVRESDEQESRSGGRSSAMRVSIERSAARSGTRRSQGNPYEGYRTRRKWTDEEENELYEMISQHGCCWSKIIHIQKLENGPLKTFGPTQIKDKARLIKARFMKQNRLQELYSKSLNWKNVTVGQAYCELHKIPYIEATPPLLREELVNYQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
330PhosphorylationKSTIGNTSNSPLQLR
HHHCCCCCCCCCHHH		39.0325720772
332PhosphorylationTIGNTSNSPLQLRAS
HCCCCCCCCCHHHHH		27.1028889911
403PhosphorylationDEASGHESDASEDTF
HHHCCCCCCCCCCCC		32.5725720772
406PhosphorylationSGHESDASEDTFSER
CCCCCCCCCCCCCHH		40.7825720772
499PhosphorylationDNLRREASLSSEQDD
HHHHHHHHCCCCCCC		24.8325720772
501PhosphorylationLRREASLSSEQDDLS
HHHHHHCCCCCCCCC		29.3625720772
502PhosphorylationRREASLSSEQDDLSE
HHHHHCCCCCCCCCC		44.5725720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAZ1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAZ1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAZ1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD3_SCHPOrad3genetic
12620220
BUB1_SCHPObub1genetic
12620220
RAD22_SCHPOrad52genetic
12620220
CDS1_SCHPOcds1genetic
12620220
TOP2_SCHPOtop2genetic
12620220
RAD50_SCHPOrad50genetic
12861005
RAD32_SCHPOmre11genetic
12861005
KU70_SCHPOpku70genetic
11172711
DNLI4_SCHPOlig4genetic
11172711
TERT_SCHPOtrt1genetic
9774280
DCR1_SCHPOdcr1genetic
16407326
RIF1_SCHPOrif1genetic
16096639
TOP2_SCHPOtop2genetic
16096639
RAP1_SCHPOrap1physical
12018857
TAZ1_SCHPOtaz1physical
10606652
RIF1_SCHPOrif1physical
11676925
RAP1_SCHPOrap1physical
11676925
RAP1_SCHPOrap1physical
11676924
ATG11_SCHPOatg11physical
11270572
RFA1_SCHPOssb1genetic
17429064
TAZ1_SCHPOtaz1physical
20074552
DNLI4_SCHPOlig4genetic
17632059
CCQ1_SCHPOccq1genetic
20040595
MPH1L_SCHPOmph1genetic
12620220
CHK1_SCHPOchk1genetic
12620220
TOP2_SCHPOtop2genetic
20495382
CCQ1_SCHPOccq1genetic
20709788
RAP1_SCHPOrap1physical
21217703
RAP1_SCHPOrap1genetic
21217703
RAP1_SCHPOrap1physical
22959349
RAD22_SCHPOrad52genetic
11172711
RFA3_SCHPOssb3genetic
22681890
RAD55_SCHPOrad55genetic
22681890
MUG33_SCHPOmug33genetic
22681890
HRQ1_SCHPOhrq1genetic
22681890
RAD57_SCHPOrad57genetic
22681890
MST2_SCHPOmst2genetic
22681890
DNLI4_SCHPOlig4genetic
23188080
RAD32_SCHPOmre11genetic
23188080
RAD50_SCHPOrad50genetic
23188080
NBS1_SCHPOnbs1genetic
23188080
KU70_SCHPOpku70genetic
23335786
DNLI4_SCHPOlig4genetic
23335786
RAD32_SCHPOmre11genetic
23335786
RAD50_SCHPOrad50genetic
23335786
NBS1_SCHPOnbs1genetic
23335786
COM1_SCHPOctp1genetic
23335786
TAZ1_SCHPOtaz1physical
26088418
TAZ1_SCHPOtaz1physical
26063574
RIF1_SCHPOrif1genetic
27320927
SWI1_SCHPOswi1genetic
26990647
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAZ1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, AND MASSSPECTROMETRY.

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