RIF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIF1_SCHPO
• UniProt AC: Q96UP3
• Protein Name: Telomere length regulator protein rif1
• Gene Name: rif1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1400
• Subcellular Localization: Nucleus . Chromosome, telomere . Localized to telomeres. This interaction may be increased by perturbation of telomere structure, for instance by loss of the rap1 protein.
• Protein Description: Negatively regulates telomere length. Appears to play no role in transcriptional silencing of telomeric loci..
• Protein Sequence: MTKEIAVKEASNMLLQEPSTPSSQAVGLSSSPSSSIRKKKVNFSSELENSPGGNRPSFGLPKRGILKTSTPLSSIKQPNFQSFEGNESEKETSLQELQSSFCSGIENLQHVEKSARIETYSKLSSFLKIYTPSLPEDPIFPLLNQLCNFLLSDRCSNNSEGSPDFQLNTQANKLLSILLWHPTISSHIQPETATVFIEQSLNFLEGPKLTKALAAQHLHLLSCQKCPLSIHPLCNRILDVCFNISFPSLVIGQERLAVLTKILSQFPLEFSRRVVDWAPYLLACLVDASRPIREKALLLALDLSKHLYHDKLVARTILANFRSDIKGTAFVLIMTEQFEKLVIEEDDGVYVAHAWAAIISVLGGARISSWEYFNTWLKIIQLCFNSMNPLTKCAAQTSWIRLIHEFSLSETLTQATKRLTLLCQPISMVLGSRNLPTVKNAAMTTLIALIYACLRPGISDAMLSLLWDSVIVNILEKCALKNEVTIFESSNILLALFNTLSNGVWKDDRLVCRESVEAKELPKLNPVWVRANCSRTIEPVKTLLLLAKPDHTVKTTTPARKQHIRGLSYEQSSSVWSTYIKCLASAGQKEIKRSVETGRAICCICSSLHKFLYSKSIRKDELYVERVSRFALMVKSAIEAFGINTFVEASYLVSDNQLVLIDQTKAIDSYDHVPISPLIYLLHSLALLTNGTLFSTVHAAYSSILSSIEEYHLRFGLKLMLLWDCVSPLSDDGTLVLARVLVSHEVSRLTSEALLSELKSRNGNNSVEEGFSEEERSILLKLLSWNVKFCSISDAGSVNNLLQQYFTAIYKFEGCGSVFPFVVDPFTTILDDVLSFEANKVYSFAISLMKVSTFESCTKELPPVTLPENIRQHLDSYNHMVELYNTLLQRLSSSDQVDLQCRYLHELSEFIKKIPKEFIFHTICKLSKGLIPCFLMNAFPQLEKSTTLQKSCTNFCILILQLLLNSTATASNILESLSPLLTSGLKSISKEVVLAAIKFWNQVFGKFESEEYPIELQKTISYLSKTYIILLPFQSLCPGGKQANHQSSEKMSDILKGVDELRSVSKNGPYASSQDKGEKTTEFSGPGKPNNDNYIQIASVQELDDSSKGKAGKMPASKKNKRQKGDVKKIDETKNEATDMEESLTTPSGKVNKEVIVDDTSLRDEAIVPDKAIDVADNSNALLKENISSQSNRKADNNGTPSVNNSFTTANNDECSKENSQIEPEGQTASREGVLSTPRSTRKKRKLGRKSQSSNVNKEVAISEVSATLENVEVIERHGISEQGQNLDESACVLTNESSLSQTEIPEEKTENETTAVNGFENSKKRQFSSLLSGSIDTNNESNKVSSVEFDKSGPQDIIQSMTEATFEIEKNIQDLKSEEVQKLSDLLMRLQRAILSRIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	QAVGLSSSPSSSIRK HCCCCCCCCCHHHCC	25.98	27738172
44	Phosphorylation	RKKKVNFSSELENSP CCCCCCCCHHHCCCC	20.07	21712547
45	Phosphorylation	KKKVNFSSELENSPG CCCCCCCHHHCCCCC	41.90	21712547
50	Phosphorylation	FSSELENSPGGNRPS CCHHHCCCCCCCCCC	18.62	24763107
57	Phosphorylation	SPGGNRPSFGLPKRG CCCCCCCCCCCCCCC	28.80	29996109
70	Phosphorylation	RGILKTSTPLSSIKQ CCCCCCCCCHHHCCC	33.22	24763107
73	Phosphorylation	LKTSTPLSSIKQPNF CCCCCCHHHCCCCCC	31.08	24763107
1146	Phosphorylation	DMEESLTTPSGKVNK CCHHHCCCCCCCCCC	22.28	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIF1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELP3_SCHPO	elp3	genetic	19547744
PLI1_SCHPO	pli1	genetic	17209013
MRC1_SCHPO	mrc1	genetic	22279046
ULP2_SCHPO	ulp2	genetic	22681890
YE08_SCHPO	SPAC17H9.08	genetic	22681890
YIDH_SCHPO	SPAC227.17c	genetic	22681890
SWI1_SCHPO	swi1	genetic	26990647

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.