NBS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NBS1_SCHPO
• UniProt AC: O43070
• Protein Name: DNA repair and telomere maintenance protein nbs1
• Gene Name: nbs1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 613
• Subcellular Localization: Nucleus . Chromosome, telomere .
• Protein Description: Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure..
• Protein Sequence: MWIIEAEGDILKGKSRILFPGTYIVGRNVSDDSSHIQVISKSISKRHARFTILTPSEKDYFTGGPCEFEVKDLDTKFGTKVNEKVVGQNGDSYKEKDLKIQLGKCPFTINAYWRSMCIQFDNPEMLSQWASNLNLLGIPTGLRDSDATTHFVMNRQAGSSITVGTMYAFLKKTVIIDDSYLQYLSTVKESVIEDASLMPDALECFKNIIKNNDQFPSSPEDCINSLEGFSCAMLNTSSESHHLLELLGLRISTFMSLGDIDKELISKTDFVVLNNAVYDSEKISFPEGIFCLTIEQLWKIIIERNSRELISKEIERLKYATASNSTPQKIIQPQRHIQKNIVDDLFSVKKPLPCSPKSKRVKTLENLSIMDFVQPKQMFGKEPEGYLSNQSNNGSAQNKKSGDNSEKTKNSLKSSSKKSANTGSGQGKTKVEYVSYNSVDKGNSSPFKPLELNVVGEKKANAEVDSLPSENVQESEDDKAFEENRRLRNLGSVEYIRIMSSEKSNANSRHTSKYYSGRKNFKKFQKKASQKAPLQAFLSLSEHKKTEVFDQDDTDLEPVPRLMSKVESIPAGASSDKSGKSSISKKSSNSFKELSPKTNNDEDDEFNDLKFHF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
325	Phosphorylation	KYATASNSTPQKIIQ HHHHCCCCCCCCHHC	38.68	24763107
326	Phosphorylation	YATASNSTPQKIIQP HHHCCCCCCCCHHCC	33.71	29996109
355	Phosphorylation	VKKPLPCSPKSKRVK CCCCCCCCCCCCCCC	33.16	28889911
444	Phosphorylation	NSVDKGNSSPFKPLE CCCCCCCCCCCCCEE	48.32	24763107
445	Phosphorylation	SVDKGNSSPFKPLEL CCCCCCCCCCCCEEE	38.05	24763107
475	Phosphorylation	PSENVQESEDDKAFE CCCCCCCCCCHHHHH	29.27	24763107
590	Phosphorylation	ISKKSSNSFKELSPK CCCCCCCCCHHCCCC	39.38	25720772
595	Phosphorylation	SNSFKELSPKTNNDE CCCCHHCCCCCCCCC	25.99	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NBS1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NBS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NBS1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEN1_SCHPO	rad2	genetic	12944481
ATM_SCHPO	tel1	physical	15964794
RAD32_SCHPO	mre11	physical	15964794
RAD32_SCHPO	mre11	physical	12944482
RAD32_SCHPO	mre11	physical	12944481
COM1_SCHPO	ctp1	physical	19804756
COM1_SCHPO	ctp1	physical	19804755
RAD3_SCHPO	rad3	genetic	20140190
CDS1_SCHPO	cds1	genetic	20065069
SWI1_SCHPO	swi1	genetic	20065069
SFR1_SCHPO	sfr1	genetic	20065069
RAD32_SCHPO	mre11	physical	23080121
RAD32_SCHPO	mre11	physical	21441914

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, AND MASSSPECTROMETRY.
PubMed: 18257517