dbPTM

PYP2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYP2_SCHPO
UniProt AC	P32586
Protein Name	Tyrosine-protein phosphatase 2
Gene Name	pyp2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	711
Subcellular Localization	Cytoplasm.
Protein Description	Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2..
Protein Sequence	MLHLLSKDEFNSTLKSFEEQTESVSWIIDLRLHSKYAVSHIKNAINVSLPTALLRRPSFDIGKVFACIKCNVKVSLDEINAIFLYDSSMAGMNRIYDLVQKFRRGGYSKKIYLLSNGFEAFASSHPDAIVSTEMVKESVPYKIDINENCKLDILHLSDPSAVSTPISPDYSFPLRVPINIPPPLCTPSVVSDTFSEFASHAEYPGFSGLTPFSIHSPTASSVRSCQSIYGSPLSPPNSAFQAEMPYFPISPAISCASSCPSTPDEQKNFFIVGNAPQQTPARPSLRSVPSYPSSNNQRRPSASRVRSFSNYVKSSNVVNPSLSQASLEIIPRKSMKRDSNAQNDGTSTMTSKLKPSVGLSNTRDAPKPGGLRRANKPCFNKETKGSIFSKENKGPFTCNPWGAKKVSPPPCEVLADLNTASIFYKFKRLEEMEMTRSLAFNDSKSDWCCLASSRSTSISRKNRYTDIVPYDKTRVRLAVPKGCSDYINASHIDVGNKKYIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSEKCSQYWPDNKDHALCLEGGLRISVQKYETFEDLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPDIESITGIIRCIDKVPNDGPMFVHCSAGVGRTGTFIAVDQILQVPKNILPKTTNLEDSKDFIFNCVNSLRSQRMKMVQNFEQFKFLYDVVDYLNSGVNQASKPLMT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
48	Phosphorylation	IKNAINVSLPTALLR HHHHHCCCCCHHHHC	24.92	21712547
51	Phosphorylation	AINVSLPTALLRRPS HHCCCCCHHHHCCCC	34.92	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PYP2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PYP2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYP2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOG1_SCHPO	sty1	genetic	7501024
WEE1_SCHPO	wee1	genetic	1448087
CDK1_SCHPO	cdc2	genetic	1448087
HOG1_SCHPO	sty1	physical	8649397
HOG1_SCHPO	sty1	physical	7657164
WEE1_SCHPO	wee1	physical	8256510
PVG2_SCHPO	pvg2	genetic	22681890
CSN3_SCHPO	csn3	genetic	22681890
PLR2_SCHPO	SPCC1281.04	genetic	22681890
UCP12_SCHPO	ucp12	genetic	22681890
G6PD2_SCHPO	zwf2	genetic	22681890
CSK2C_SCHPO	ckb2	genetic	22681890
RS3_SCHPO	rps3	genetic	22681890
DIL1_SCHPO	dli1	genetic	22681890
AP2M_SCHPO	apm4	genetic	22681890
DBR1_SCHPO	dbr1	genetic	22681890
MU147_SCHPO	mug147	genetic	22681890
PPT1_SCHPO	SPBC3F6.01c	genetic	22681890
WTF21_SCHPO	wtf21	genetic	22681890
MBO1_SCHPO	mto1	genetic	22681890
CAPZA_SCHPO	acp1	genetic	22681890
YE08_SCHPO	SPAC17H9.08	genetic	22681890
YGWH_SCHPO	gmh4	genetic	22681890
YAQC_SCHPO	SPAC18G6.12c	genetic	22681890
UDS1_SCHPO	uds1	genetic	22681890
HMT2_SCHPO	hmt2	genetic	22681890
TVP18_SCHPO	SPBC32F12.12c	genetic	22681890
GBB_SCHPO	git5	genetic	22681890
VPS38_SCHPO	vps38	genetic	22681890
PFD3_SCHPO	pac10	genetic	22681890
TRM13_SCHPO	trm13	genetic	22681890
SCS7_SCHPO	scs7	genetic	22681890
YJD1_SCHPO	SPCC594.01	genetic	22681890
YDT7_SCHPO	SPAC6B12.07c	genetic	22681890
YB35_SCHPO	SPBC2F12.05c	genetic	22681890
VPS72_SCHPO	swc2	genetic	22681890
GLD1_SCHPO	gld1	genetic	22681890
OAZ_SCHPO	spa1	genetic	22681890
YA4C_SCHPO	SPAC31A2.12	genetic	22681890
YAM5_SCHPO	mso1	genetic	22681890
RFP2_SCHPO	rfp2	genetic	22681890
YA32_SCHPO	SPAC18B11.02c	genetic	22681890
YQMA_SCHPO	SPCP1E11.10	genetic	22681890
RS4C_SCHPO	rps403	genetic	22681890
PRZ1_SCHPO	prz1	genetic	22681890
MUG51_SCHPO	mug51	genetic	22681890
YKEE_SCHPO	SPAC1805.14	genetic	22681890
UGE1_SCHPO	uge1	genetic	22681890
MOC3_SCHPO	moc3	genetic	22681890
HOG1_SCHPO	sty1	physical	23690545
HOG1_SCHPO	sty1	physical	23695164
HOG1_SCHPO	sty1	physical	26771498
TNR3_SCHPO	tnr3	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PYP2_SCHPO

Related Literatures of Post-Translational Modification