CKI3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CKI3_SCHPO
• UniProt AC: O74135
• Protein Name: Casein kinase I homolog 3
• Gene Name: cki3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 439
• Subcellular Localization: Cytoplasm.
• Protein Description: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates..
• Protein Sequence: MSTTSSHSNVVGVHYRVGKKIGEGSFGMLFQGVNLINNQPIALKFESRKSEVPQLRDEYLTYKLLMGLPGIPSVYYYGQEGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMITRIQSVHERHFIYRDIKPDNFLIGFPGSKTENVIYAVDFGMAKQYRDPKTHVHRPYNEHKSLSGTARYMSINTHLGREQSRRDDLESMGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQVTPLKELCEGYPKEFLQYMIYARNLGYEEAPDYDYLRSLFDSLLLRINETDDGKYDWTLLNNGKGWQYSAAKQHVVQRRHTQGTNNRRQSTIPPYARTRQNLLSSPSKQTPVNNVVDASVATQKDGIPGKAASPQVQQQQQTSSAQQQQPQRVEQPAPQTTQPTQVDTQQAAKPAPSKEKSRKKFHLRLLSCCISKQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTTSSHSN ------CCCCCCCCC	40.15	21712547
3	Phosphorylation	-----MSTTSSHSNV -----CCCCCCCCCE	29.42	21712547
4	Phosphorylation	----MSTTSSHSNVV ----CCCCCCCCCEE	22.41	24763107
5	Phosphorylation	---MSTTSSHSNVVG ---CCCCCCCCCEEE	26.58	21712547
6	Phosphorylation	--MSTTSSHSNVVGV --CCCCCCCCCEEEE	28.92	21712547
8	Phosphorylation	MSTTSSHSNVVGVHY CCCCCCCCCEEEEEE	33.01	21712547
331	Phosphorylation	GTNNRRQSTIPPYAR CCCCCCCCCCCCCHH	26.88	29996109
332	Phosphorylation	TNNRRQSTIPPYART CCCCCCCCCCCCHHH	29.21	25720772
336	Phosphorylation	RQSTIPPYARTRQNL CCCCCCCCHHHHHHH	11.89	25720772
339	Phosphorylation	TIPPYARTRQNLLSS CCCCCHHHHHHHHCC	28.56	25720772
345	Phosphorylation	RTRQNLLSSPSKQTP HHHHHHHCCCCCCCC	43.29	25720772
346	Phosphorylation	TRQNLLSSPSKQTPV HHHHHHCCCCCCCCC	32.91	25720772
348	Phosphorylation	QNLLSSPSKQTPVNN HHHHCCCCCCCCCCC	39.07	29996109
360	Phosphorylation	VNNVVDASVATQKDG CCCEEEHHHHCCCCC	14.07	21712547
363	Phosphorylation	VVDASVATQKDGIPG EEEHHHHCCCCCCCC	33.71	24763107
374	Phosphorylation	GIPGKAASPQVQQQQ CCCCCCCCHHHHHHH	22.26	25720772
383	Phosphorylation	QVQQQQQTSSAQQQQ HHHHHHHCCHHHHHC	21.95	21712547
384	Phosphorylation	VQQQQQTSSAQQQQP HHHHHHCCHHHHHCC	21.24	29996109
385	Phosphorylation	QQQQQTSSAQQQQPQ HHHHHCCHHHHHCCC	33.22	25720772
409	Phosphorylation	TQPTQVDTQQAAKPA CCCCCCCHHHHCCCC	24.59	29996109
418	Phosphorylation	QAAKPAPSKEKSRKK HHCCCCCCCHHHHHH	56.40	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CKI3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CKI3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CKI3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2B_SCHPO	ppb1	physical	25691662

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.