| UniProt ID | DNLI1_SCHPO | |
|---|---|---|
| UniProt AC | P12000 | |
| Protein Name | DNA ligase 1 | |
| Gene Name | cdc17 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 768 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.. | |
| Protein Sequence | MRTVFSQIPRFKQVNQYIRMSTRQSDISNFFISSASHKSEHVEVSQSSSDSKNVDGRSTSEKRKVESVKLVDESKHNNHDDTGTQNVERENNIVSEAKKQKTLGSSSSSSDAVSSNNDSGASTPIPLPIKEPPLESNARNDKLKGHATFAEMVKAFTKIENTSKRLEIIDIMGTYFFGILRDHPSDLLACVYLSINKLGPDYSGLELGIGESIIMKAIGESTGQTLQQIKLSFHKVGDLGLVAQTSRQNQPTMFKPAALTIPFLFDSLKKIAQMSGNQSQNRKIGVIKRLLSSCEGAEPKYLIRALEGKLRLQLAEKTILVALANATAQYHADKNGEKLSQQDRIEGEQILRDVYCQLPSYDLIVPHLIEHGLGTLRETCKLTPGIPTKPMLAKPTKQISEVLNTFDQAAFTCEYKYDGERAQVHFTEDGKFYVFSRNSENMSVRYPDISVSVSKWKKPDARSFILDCEAVGWDRDENKILPFQKLATRKRKDVKIGDIKVRACLFAFDILYLNGQPLLETPLNERRKLLYSMFQPSTGDFTFAKHSDQKSIESIEEFLEESVKDSCEGLMVKMLEGPDSHYEPSKRSRHWLKVKKDYLSGVGDSLDLIVIGAYYGKGKRTSVYGAFLLGCYDPDTETVQSICKLGTGFSEEHLETFYNQLKDIVISKKKDFYAHSDVPAHQPDVWFEPKYLWEVLAADLSLSPVYKAAIGYVQEDKGISLRFPRFIRIREDKSWEDATTSEQVSEFYRSQVAYSQKEKEGSPAAEDY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | Phosphorylation | EHVEVSQSSSDSKNV CCEEECCCCCCCCCC | 25.05 | 25720772 | |
| 114 | Phosphorylation | SSSSDAVSSNNDSGA CCCCCCHHCCCCCCC | 29.12 | 25720772 | |
| 119 | Phosphorylation | AVSSNNDSGASTPIP CHHCCCCCCCCCCCC | 38.08 | 21712547 | |
| 122 | Phosphorylation | SNNDSGASTPIPLPI CCCCCCCCCCCCCCC | 37.94 | 25720772 | |
| 123 | Phosphorylation | NNDSGASTPIPLPIK CCCCCCCCCCCCCCC | 25.38 | 25720772 | |
| 551 | Phosphorylation | AKHSDQKSIESIEEF CCCCCCCCHHHHHHH | 26.42 | 21712547 | |
| 554 | Phosphorylation | SDQKSIESIEEFLEE CCCCCHHHHHHHHHH | 33.36 | 21712547 | |
| 762 | Phosphorylation | SQKEKEGSPAAEDY- HHHHCCCCCCCCCC- | 16.68 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DNLI1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DNLI1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DNLI1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MSC1_SCHPO | msc1 | genetic | 15082762 | |
| CHK1_SCHPO | chk1 | genetic | 15585577 | |
| PCNA_SCHPO | pcn1 | physical | 14752051 | |
| RAD3_SCHPO | rad3 | genetic | 1594599 | |
| PCNA_SCHPO | pcn1 | physical | 22308326 | |
| FEN1_SCHPO | rad2 | genetic | 9891047 | |
| CDS1_SCHPO | cds1 | genetic | 9891047 | |
| RAD26_SCHPO | rad26 | genetic | 9891047 | |
| HUS2_SCHPO | rqh1 | genetic | 9891047 | |
| AP1_SCHPO | pap1 | genetic | 24587136 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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