| UniProt ID | CSN5_SCHPO | |
|---|---|---|
| UniProt AC | O94454 | |
| Protein Name | COP9 signalosome complex subunit 5 | |
| Gene Name | csn5 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 299 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.. | |
| Protein Sequence | MNNQLENVFRFDEEKERAKIRESPWKHDPEFFRSVKISAVALLKMLRHVSQGMPLEVMGYVQGKVEGASLIILDSFALPVEGTETRVNAHEEAQEYSVQYHTLCKSVYRHENVIGWYHSHPNYGCWLSGVDVETQRQNQKYQDPFVAVVLDPKRSLESPYVNIGAFRTYPVGNDGSIRTKSRHHPSVLFKNLPSSKIEDAGAHAEAYYSLPITYFHSKAEKKVTEFLRNRNWSRSITECSILQNNEFLHDSEKLIDHLIHETGNNELPVASAYEQSKACCNELSTFLSQIDVQDKLFKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of CSN5_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CSN5_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CSN5_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CSN5_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CSN2_SCHPO | csn2 | physical | 11854407 | |
| NESP1_SCHPO | nep1 | physical | 15769255 | |
| CUL3_SCHPO | cul3 | physical | 11504566 | |
| SKP1_SCHPO | skp1 | genetic | 19748355 | |
| NDK_SCHPO | ndk1 | genetic | 18818364 | |
| MCL1_SCHPO | mcl1 | genetic | 18818364 | |
| SGF29_SCHPO | sgf29 | genetic | 18818364 | |
| VPH2_SCHPO | vph2 | genetic | 18818364 | |
| YFE6_SCHPO | gmh5 | genetic | 18818364 | |
| DCR1_SCHPO | dcr1 | genetic | 18818364 | |
| CUL1_SCHPO | cul1 | physical | 12183637 | |
| NSE6_SCHPO | nse6 | genetic | 22681890 | |
| MGR2_SCHPO | mgr2 | genetic | 22681890 | |
| YE08_SCHPO | SPAC17H9.08 | genetic | 22681890 | |
| GPA2_SCHPO | gpa2 | genetic | 22681890 | |
| ERS1_SCHPO | ers1 | genetic | 22681890 | |
| RPB9_SCHPO | rpb9 | genetic | 22681890 | |
| EMC1_SCHPO | emc1 | genetic | 22681890 | |
| MCL1_SCHPO | mcl1 | genetic | 22681890 | |
| UBLH1_SCHPO | uch1 | genetic | 23496905 | |
| UBLH2_SCHPO | uch2 | genetic | 23496905 | |
| NESP1_SCHPO | nep1 | genetic | 23496905 | |
| NEP2_SCHPO | nep2 | genetic | 23496905 | |
| CSN5_SCHPO | csn5 | physical | 26771498 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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