| UniProt ID | NESP1_SCHPO | |
|---|---|---|
| UniProt AC | O42980 | |
| Protein Name | NEDD8-specific protease 1 | |
| Gene Name | nep1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 420 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins.. | |
| Protein Sequence | MSSSPTVLELFDVCFKQEDVDSLKKPNWFTDVSIDYVDELIEHLWFPSYPNQANEILLLRPSLVFLLAEAAISPEELKVALPKKLMNCKYLFMPINDLDKHAAGSGGSHWSLMVASIPDGQCYYYDSLSNGKTKDCRSALARVSDLFKKKFTIECMPVQQQRNGYDCGAHVCAFTLELVRRLLHSPMPTSSMWNLSTFQPDVTAIREQLSRCLDHIINSLGTRVSGDFDEDFPTGTVFFDLESHLPLLDVALPVLPKSSDSSETSHESSNSNLKKSSESGSTNHHNNHESDKDLHHEGHHHHHHHHHHHHSHDDDPSSPAEKKQNHVPSPSEKIQDHVPSPSEKKQDRVPSPSNNKEDHLPLLSDEKLDKSAIDKIEPTPLPSVHMNSHIAKGELPKFHNSTDNPFLTPPEELVSGDFPF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 329 | Phosphorylation | KKQNHVPSPSEKIQD HHHCCCCCCCHHHHH | 28889911 | ||
| 331 | Phosphorylation | QNHVPSPSEKIQDHV HCCCCCCCHHHHHCC | 21712547 | ||
| 340 | Phosphorylation | KIQDHVPSPSEKKQD HHHHCCCCCCHHCCC | 28889911 | ||
| 342 | Phosphorylation | QDHVPSPSEKKQDRV HHCCCCCCHHCCCCC | 29996109 | ||
| 351 | Phosphorylation | KKQDRVPSPSNNKED HCCCCCCCCCCCCCC | 28889911 | ||
| 353 | Phosphorylation | QDRVPSPSNNKEDHL CCCCCCCCCCCCCCC | 24763107 | ||
| 364 | Phosphorylation | EDHLPLLSDEKLDKS CCCCCCCCCCCCCHH | 21712547 | ||
| 408 | Phosphorylation | STDNPFLTPPEELVS CCCCCCCCCHHHHCC | 24763107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NESP1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NESP1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NESP1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MAD2_SCHPO | mad2 | genetic | 15769255 | |
| CUL1_SCHPO | cul1 | physical | 15769255 | |
| CUL3_SCHPO | cul3 | physical | 15769255 | |
| CUL4_SCHPO | pcu4 | physical | 15769255 | |
| UBL1_SCHPO | ned8 | physical | 23496905 | |
| UBLH1_SCHPO | uch1 | genetic | 23496905 | |
| UBLH2_SCHPO | uch2 | genetic | 23496905 | |
| NEP2_SCHPO | nep2 | genetic | 23496905 | |
| CSN5_SCHPO | csn5 | genetic | 23496905 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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