dbPTM

CDC37_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDC37_SCHPO
UniProt AC	O94740
Protein Name	Hsp90 co-chaperone Cdc37
Gene Name	cdc37
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	466
Subcellular Localization	Nucleus. Cytoplasm. When in the nucleus associated with chromatin.
Protein Description	Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity..
Protein Sequence	MAIDYSKWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAVRKQKMEDIKGAMAMNRRLLSRISEMETVLEKESPSDPYVLLGSFLEAKKSEDMDSAIPGGMSYHHMLMSLLKVIKDAEDTTEEKSMDDSDKCLRRLKSHKERLLKLLEDAQKEYDTLEAESKNYITSEDLHLGFDSTYVQKKEPEKPKKTKTKKETIQVIESLNNPTPPTDFPGAKEQASTGNAPKNPVNENESEDEEGLSLSEDGKKFANIDFGDYSSSEEFLKEHLNILADEEESDAILLEAFNAELEGKPSLAKQYVHQALLISYCRQLGPNGLSIFFQKIKDPNHQSQRLFLEDVHNTYVRIHERSAAISKEQAESGEGVEQIQLCAVDPNTKLSITIPEAGSTDPETQKARAAFESFPPNLQKALMTNDLDKINVVLGKMAVENAEEVVEKLSSTGMLSIEEGIIDTTKGETIPQLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KWDKLELSDDSDIEV HCCCCCCCCCCCCEE	29.96	24763107
17	Phosphorylation	KLELSDDSDIEVHPN CCCCCCCCCCEECCC	45.54	24763107
238	Phosphorylation	NPVNENESEDEEGLS CCCCCCCCCCCCCCC	63.03	28889911
245	Phosphorylation	SEDEEGLSLSEDGKK CCCCCCCCCCCCCCE	40.48	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDC37_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDC37_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDC37_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK1_SCHPO	cdc2	genetic	16390871
HSP90_SCHPO	hsp90	genetic	16098195
CDK1_SCHPO	cdc2	physical	16390871
HSP90_SCHPO	hsp90	physical	16098195
RYH1_SCHPO	ryh1	genetic	22681890
FHL1_SCHPO	fhl1	genetic	22681890
PROB_SCHPO	SPAC17H9.13c	genetic	22681890
LYS1_SCHPO	lys3	genetic	22681890
ATP10_SCHPO	atp10	genetic	22681890
EFTS_SCHPO	tsf1	genetic	22681890
ARGJ_SCHPO	SPBC1271.14	genetic	22681890
OTC_SCHPO	arg3	genetic	22681890
POM1_SCHPO	pom1	genetic	22681890
NAGS_SCHPO	arg6	genetic	22681890
HOSM_SCHPO	lys4	genetic	22681890
LYS4_SCHPO	lys2	genetic	22681890
TR112_SCHPO	trm112	genetic	22681890
AROG_SCHPO	SPAP8A3.07c	genetic	22681890
YF75_SCHPO	spa2	genetic	22681890
AATM_SCHPO	SPBC725.01	genetic	22681890
YCF8_SCHPO	SPCC1393.08	genetic	22681890
RM01_SCHPO	SPAC1610.02c	genetic	22681890
ARG56_SCHPO	arg11	genetic	22681890
RL16B_SCHPO	rpl1601	genetic	22681890
RL21B_SCHPO	rpl2102	genetic	22681890
MPC1_SCHPO	mpc1	genetic	22681890
PRZ1_SCHPO	prz1	genetic	22681890
ASSY_SCHPO	arg12	genetic	22681890
YQK8_SCHPO	SPCC1494.08c	genetic	22681890
LYS12_SCHPO	lys12	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDC37_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.	18257517 [Abstract]