dbPTM

KLP8_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KLP8_SCHPO
UniProt AC	Q9UTL2
Protein Name	Kinesin-like protein 8
Gene Name	klp8
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	511
Subcellular Localization	Cytoplasm, cytoskeleton .
Protein Description
Protein Sequence	MSTANVRVIVRVRPKSLRELSKSAEDLLSVDSHNKTVTITPPKHGLKHSRHKNRVNGPRTFAFDECFAPSAPESKNLSGQEDVYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVGLRGQPGIIPHISESIFEEIDKLKKKSPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDSLTGYHLHGLSEFEVGSAQEIDAFLRLAAKNIRTELSDISGVRKGHSVFSLVVQQRIIDPKTRHSLKKASRLQIIDLASFSKGSQRNESISSFESSSNNKSLSVLNRVIAALTSKKNDVLIPYKDSVLTTLLQDALGGNCRTIMLTCVSPCDFDDTFSALRYSEAARRIKNISNINCKEAYSTNNEGELDDILTTLESDREQLRRHEEHSQKLLKFIEEIRNDYEERIHALESQNSALKAHLRLAVDAYLNPLEFNFDDKNVKLKEFGSPNIAYKQELNSFQGELSSLFKDLKLVKSQLHDYPKPEVSDIDMDMESLRHDSLLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	SLRELSKSAEDLLSV HHHHHHHCHHHHHCC	33.25	24763107
271	Phosphorylation	LASFSKGSQRNESIS HHHCCCCCCCCCCCC	29.69	24763107
276	Phosphorylation	KGSQRNESISSFESS CCCCCCCCCCCCCCC	31.18	21712547
278	Phosphorylation	SQRNESISSFESSSN CCCCCCCCCCCCCCC	37.95	28889911
279	Phosphorylation	QRNESISSFESSSNN CCCCCCCCCCCCCCC	31.22	28889911
282	Phosphorylation	ESISSFESSSNNKSL CCCCCCCCCCCCCHH	36.74	25720772
284	Phosphorylation	ISSFESSSNNKSLSV CCCCCCCCCCCHHHH	54.42	28889911
301	Phosphorylation	RVIAALTSKKNDVLI HHHHHHHCCCCCEEE	42.35	29996109
456	Phosphorylation	VKLKEFGSPNIAYKQ CEEHHHCCCCCHHHH	21.79	28889911
467	Phosphorylation	AYKQELNSFQGELSS HHHHHHHHHHHHHHH	31.41	25720772
508	Phosphorylation	MESLRHDSLLD---- HHHHCCCCCCC----	25.38	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KLP8_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KLP8_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KLP8_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KLP8_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KLP8_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278; SER-279; SER-284AND SER-456, AND MASS SPECTROMETRY.	18257517 [Abstract]