DI3L2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DI3L2_SCHPO
• UniProt AC: O14040
• Protein Name: DIS3-like exonuclease 2 {ECO:0000255|HAMAP-Rule:MF_03045}
• Gene Name: dis32
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 927
• Subcellular Localization: Cytoplasm . Cytoplasm, P-body .
• Protein Description: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'..
• Protein Sequence: MDLKPNIRRKEKRNLLKGEAALEKKGSIDRKTKNKAYPSTTHDPHQNDDSNIPGLGSGLLERIKDIVQRPTDTQLKGQDSNHKKASLTETKTEKAKVKPKAKKKNSKEKISKSSKQDEHKTDVHKESVSKLSKNLESRNNRDENSAKREKNNSHQVEADTNNATEMVSSNAKKSVYPLYYDSATVKKGLKSGTLFKGTLRILENHRSAFACMEDIPDFYVDGPIARNRAFHNDVVIVEPVMNNDSPTEKSNFLQNGVEKVKIKDHDDELGGAMEHLERLEIKSVASFKGDSRTRARVVAIEKRAEISKIVGILRAPGWSLKNVEYVSKKSSYAIFIPKDKRLPFITIHKNDLSDLSGENWIENILKHHDQLFSVEITRWSIYSRYPMGVLGEKLGNITDVEAYTNALLLENGISSSPFSDEVLNCLPPDDWIISHEEIKKRRDLRNELIITIDPETARDLDDAVSCRALDNGTYEVGVHIADVTHFVKPDSALDKEAASRATTVYLVQKAIPMLPPLLCERLCSLNPNVERLAFSVFWKLDSNGKEIGKRWFGKTVIKTCARLAYSEAQGVIEGKSWDDAVGKPIGGTHTPKDVETSILTLCEISRKLRKDRFAKGAVEINSTELKFQLDEYGMPNKCEVYEQTDANHLIEEFMLLANRSVAEHISKNFSNNSLLRRHASPKEKQINEFCHFLKSMNFDFDASSSAAFNASMVRLRSTFNEELVELFENMAVRSLNRAEYFCTGDFGEKTDWHHYALSFNHYTHFTSPIRRYPDIIVHRLLERSLKNTSPGIDKKNCSLVAAHCNEKKEKSTTVQEDSQQLFLSVYIAEYCKKHDKKSMPVQAFATRISGNSIDVYISEYGISNRVDLSSDDRIKSFIVAPDDSSVKITLFDDSQKTIALTDRFQVYLYSDYSRTFFSIRCSLVSLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	AALEKKGSIDRKTKN HHHHHCCCCCHHCCC		21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DI3L2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DI3L2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DI3L2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRN1_SCHPO	exo2	genetic	23503588
LSM1_SCHPO	lsm1	genetic	23503588

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.