SWC4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SWC4_SCHPO
• UniProt AC: O14308
• Protein Name: SWR1-complex protein 4
• Gene Name: swc4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 437
• Subcellular Localization: Nucleus.
• Protein Description: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity)..
• Protein Sequence: MTSADIRDVFELPPPEIGNKQKSKTPTERRPEGISRELYSLLGENSAPLAIYQKKFKEKPKVSHKAKNWVRQPFSISSRKDDFTLHHWVLKSEVDSEASYKFEKFNVPLFIIDYTDEEYQNYLKDEDWNKDETDYLFRLCKDYDLRFFVIADRYDNEKYKKHRTLEDLKDRFYSVSRKILLARNPINSMTAAQSSLLNTMEYNKEQEVIRKKYLIGLASRTPEEVAEEEALFIELKRIETSQAKLLSDRDEVLRLLDEQKGDGGIHEYHTSAGMSSLIQDMINSQRTKNKVEEAIVSSSAPSSGVSSVLNTPTRPHALSTPRIRYGPQPTDPQFGITWHEKLHPGTFVRSQKIPAIKASLSQRVSSVMTELGVSSRLIMPTAKNFEKFVELQNSIVSLLELKRKVDRLSQETEIQDKLSRKRSASPDGSESKKHISQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
302	Phosphorylation	IVSSSAPSSGVSSVL HHHCCCCCCCCCCHH	39.17	29996109
303	Phosphorylation	VSSSAPSSGVSSVLN HHCCCCCCCCCCHHC	42.00	29996109
306	Phosphorylation	SAPSSGVSSVLNTPT CCCCCCCCCHHCCCC	20.46	29996109
307	Phosphorylation	APSSGVSSVLNTPTR CCCCCCCCHHCCCCC	28.37	29996109
311	Phosphorylation	GVSSVLNTPTRPHAL CCCCHHCCCCCCCCC	23.13	29996109
419	Phosphorylation	TEIQDKLSRKRSASP HHHHHHHHHHCCCCC	41.31	21712547
423	Phosphorylation	DKLSRKRSASPDGSE HHHHHHCCCCCCCHH	35.81	21712547
425	Phosphorylation	LSRKRSASPDGSESK HHHHCCCCCCCHHHH	25.44	21712547
429	Phosphorylation	RSASPDGSESKKHIS CCCCCCCHHHHHCCC	46.18	21712547
431	Phosphorylation	ASPDGSESKKHISQ- CCCCCHHHHHCCCC-	49.02	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SWC4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SWC4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SWC4_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of SWC4_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.