NED1_SCHPO - dbPTM
NED1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NED1_SCHPO
UniProt AC Q9UUJ6
Protein Name Nuclear elongation and deformation protein 1
Gene Name ned1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 656
Subcellular Localization
Protein Description May have a role in the maintenance of the nuclear envelope structure and in minichromosome stability..
Protein Sequence MQYVGRAFDSVTKTWNAINPSTLSGAIDVIVVEQEDKTLACSPFHVRFGKFSLLLPSDKKVEFSVNGQLTGFNMKLGDGGEAFFVFATENAVPRELQTSPIVSPTTSPKQTPSINVTEPQDLELDKVSQDHEKDQSNTYLMEDGYEFPLTRDLIRRSKSDADQTPPTGFKHLRHSSCLEMAGSDRTPSMPATTLADLRLLQKAKELGKRLSGKELPTRVGDNGDVMLDMTGYKSSAANINIAELARETFKDEFPMIEKLLREDEEGNLWFHASEDAKKFAEVYGHSPPASPSRTPASPKSDSALMDEDSDLSRRHSLSEQSLSPVSESYPQYAKTLRLTSDQLRSLNLKPGKNELSFGVNGGKAICTANLFFWKHNDPVVISDIDGTITKSDALGHMFTLIGKDWTHAGVAKLYTDITNNGYKIMYLTSRSVGQADSTRHYLRNIEQNGYSLPDGPVILSPDRTMAALHREVILRKPEVFKMACLRDLCNIFALPVPRTPFYAGFGNRITDAISYNHVRVPPTRIFTINSAGEVHIELLQRSGHRSSYVYMNELVDHFFPPIEVSTRDEVSSFTDVNFWRSPLLELSDEEEDDTNKSTSKSPKTPKNTKFGYQEFEGIDEEDAQDYSPSPLIKSFNELMFEGEEDEEGEEDVENAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
98PhosphorylationAVPRELQTSPIVSPT
CCCCHHCCCCCCCCC		49.4429996109
99PhosphorylationVPRELQTSPIVSPTT
CCCHHCCCCCCCCCC		10.3228889911
103PhosphorylationLQTSPIVSPTTSPKQ
HCCCCCCCCCCCCCC		19.7628889911
105PhosphorylationTSPIVSPTTSPKQTP
CCCCCCCCCCCCCCC		32.1924763107
106PhosphorylationSPIVSPTTSPKQTPS
CCCCCCCCCCCCCCC		46.5528889911
107PhosphorylationPIVSPTTSPKQTPSI
CCCCCCCCCCCCCCC		32.3628889911
113PhosphorylationTSPKQTPSINVTEPQ
CCCCCCCCCCCCCCC		30.1328889911
157PhosphorylationTRDLIRRSKSDADQT
CHHHHHHCCCCCCCC		27.0229996109
159PhosphorylationDLIRRSKSDADQTPP
HHHHHCCCCCCCCCC		39.0028889911
164PhosphorylationSKSDADQTPPTGFKH
CCCCCCCCCCCCCHH		31.6129996109
175PhosphorylationGFKHLRHSSCLEMAG
CCHHHCCCHHHHHCC		19.1329996109
176PhosphorylationFKHLRHSSCLEMAGS
CHHHCCCHHHHHCCC		19.3225720772
283PhosphorylationAKKFAEVYGHSPPAS
HHHHHHHHCCCCCCC		10.7125720772
286PhosphorylationFAEVYGHSPPASPSR
HHHHHCCCCCCCCCC		28.3728889911
290PhosphorylationYGHSPPASPSRTPAS
HCCCCCCCCCCCCCC		29.2228889911
292PhosphorylationHSPPASPSRTPASPK
CCCCCCCCCCCCCCC		46.4121712547
294PhosphorylationPPASPSRTPASPKSD
CCCCCCCCCCCCCCC		27.7821712547
297PhosphorylationSPSRTPASPKSDSAL
CCCCCCCCCCCCCCC		33.7824763107
300PhosphorylationRTPASPKSDSALMDE
CCCCCCCCCCCCCCC		39.9329996109
302PhosphorylationPASPKSDSALMDEDS
CCCCCCCCCCCCCCC		30.3229996109
312PhosphorylationMDEDSDLSRRHSLSE
CCCCCCHHHHHCCCH		32.0529996109
316PhosphorylationSDLSRRHSLSEQSLS
CCHHHHHCCCHHCCC		31.6028889911
318PhosphorylationLSRRHSLSEQSLSPV
HHHHHCCCHHCCCCC		36.2828889911
321PhosphorylationRHSLSEQSLSPVSES
HHCCCHHCCCCCCCC		27.1128889911
572PhosphorylationSTRDEVSSFTDVNFW
ECCCCCCCCCCCCCC		37.0225720772
587PhosphorylationRSPLLELSDEEEDDT
CCCCCCCCCCCCCCC		33.3312376568
594PhosphorylationSDEEEDDTNKSTSKS
CCCCCCCCCCCCCCC		57.7925720772
597PhosphorylationEEDDTNKSTSKSPKT
CCCCCCCCCCCCCCC		39.7325720772
601PhosphorylationTNKSTSKSPKTPKNT
CCCCCCCCCCCCCCC		31.2525720772
626PhosphorylationDEEDAQDYSPSPLIK
CHHHHCCCCCCHHHH		15.4821712547
627PhosphorylationEEDAQDYSPSPLIKS
HHHHCCCCCCHHHHH		27.4721712547
629PhosphorylationDAQDYSPSPLIKSFN
HHCCCCCCHHHHHHH		26.8021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NED1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NED1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NED1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RCC1_SCHPOpim1genetic
12376568
SPI1_SCHPOspi1genetic
12376568
DIS3_SCHPOdis3physical
12376568
RCC1_SCHPOpim1physical
12376568
NU189_SCHPOnup189physical
12376568
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NED1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-103; THR-106;SER-107; SER-159; SER-286; SER-318; SER-321 AND SER-587, AND MASSSPECTROMETRY.

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