dbPTM

SPI1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPI1_SCHPO
UniProt AC	P28748
Protein Name	GTP-binding nuclear protein spi1
Gene Name	spi1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	216
Subcellular Localization	Nucleus.
Protein Description	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export..
Protein Sequence	MAQPQNVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLHFHTNFGEICFNVWDTAGQEKLGGLRDGYYIQGQCGIIMFDVTSRITYKNVPHWWRDLVRVCENIPIVLCGNKVDVKERKVKAKAITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPNLEFVASPALAPPEVQVDQQLLAQYQQEMNEAAAMPLPDEDDADL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
20	Phosphorylation	VLVGDGGTGKTTFVK EEEECCCCCCCEEEE	40.82	28889911
149	Phosphorylation	NLQYYDISAKSNYNF CCEEEECCCCCCCCC	27.09	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPI1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPI1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPI1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DIS3_SCHPO	dis3	physical	8896453
RCC1_SCHPO	pim1	genetic	11086011
NDC1_SCHPO	cut11	genetic	11086011
MAL3_SCHPO	mal3	genetic	11086011
RCC1_SCHPO	pim1	physical	8887664
RANG_SCHPO	sbp1	physical	11086011
RCC1_SCHPO	pim1	physical	16371130
FFT3_SCHPO	fft3	physical	18422602
SPC7_SCHPO	spc7	genetic	15371542
CSE1_SCHPO	kap109	physical	26771498
XPOT_SCHPO	los1	physical	26771498
MOG1_SCHPO	mog1	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPI1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20, AND MASSSPECTROMETRY.	18257517 [Abstract]