| UniProt ID | NDC1_SCHPO | |
|---|---|---|
| UniProt AC | O13961 | |
| Protein Name | Nuclear envelope protein ndc1 | |
| Gene Name | cut11 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 601 | |
| Subcellular Localization |
Nucleus, nuclear pore complex. Nucleus membrane Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Central core structure of the nuclear pore complex. |
|
| Protein Description | Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope.. | |
| Protein Sequence | MVMLRTSFPSGSRTKAVRYHTLLRPILQQRFLRACFALLCLCCITSYWFSSGPFISLSFWFLSLVRGFVCFFFMFPYFVMLKSRMSTQKVTKQSLGAQLFYDFSPKSFFLVYLTFAVSVSCLCLFYIKGHASSIRLQWIASPNAYELPSLNERFVYMTYFSHILILALTVEHLYLQRDSPSRPVINVSFFNYIFQNLGWLIRFSFRKSIICCLFTPFSYAILRSYIWRFAALLTSCCRRIAYTKTPPKWPLSLRLLLHSFWMAFIVCLTFQIALLIFRVFLYSGPMIRGKLLSARSNDPNGTLVDGMKTKKKPLTECIATEELWFIAKRDPQRIKSIFQDIDRSVSIWQELYSITESRCKELATSLKILQSTGDFSAATSKKSGLTKKTNIPYSPNSNHEEINSIPLRNKNIFVPPSQGHSPLLEKIKKQGSLPSTTPVNEGGISDIIPKSLYDQVIRFISTFYKAPVFGIFRKTLRRQNEALLPNPWLFCVTVNSLTQLVLKSLKYDTYGVVARDISSILAVYCDTFDVLVSYKRSLVKNHSNSTNLDDDFKNLNSAANALHCGIIDITEKFQDFFTQLNLSPRIERRCWVLFREYKSNS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MVMLRTSFPSGSR --CCEEEECCCCCCC | 30.66 | 21712547 | |
| 7 | Phosphorylation | -MVMLRTSFPSGSRT -CCEEEECCCCCCCC | 28.82 | 21712547 | |
| 10 | Phosphorylation | MLRTSFPSGSRTKAV EEEECCCCCCCCHHH | 47.60 | 21712547 | |
| 393 | Phosphorylation | TKKTNIPYSPNSNHE CCCCCCCCCCCCCCH | 32.72 | 29996109 | |
| 394 | Phosphorylation | KKTNIPYSPNSNHEE CCCCCCCCCCCCCHH | 16.55 | 25720772 | |
| 397 | Phosphorylation | NIPYSPNSNHEEINS CCCCCCCCCCHHHCC | 42.84 | 29996109 | |
| 417 | Phosphorylation | KNIFVPPSQGHSPLL CCEECCCCCCCCHHH | 42.60 | 21712547 | |
| 421 | Phosphorylation | VPPSQGHSPLLEKIK CCCCCCCCHHHHHHH | 24.86 | 24763107 | |
| 451 | Phosphorylation | ISDIIPKSLYDQVIR HHHCCCHHHHHHHHH | 27.14 | 25720772 | |
| 583 | Phosphorylation | FFTQLNLSPRIERRC HHHHCCCCHHHHHHH | 15.85 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NDC1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDC1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDC1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KLP1_SCHPO | pkl1 | genetic | 11694582 | |
| CUT12_SCHPO | cut12 | genetic | 9763447 | |
| TBB_SCHPO | nda3 | genetic | 9763447 | |
| BRR6_SCHPO | brr6 | genetic | 22042620 | |
| APQ12_SCHPO | apq12 | genetic | 22042620 | |
| TTS1_SCHPO | tts1 | genetic | 25103238 | |
| SAD1_SCHPO | sad1 | genetic | 27889481 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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