BRR6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRR6_SCHPO
• UniProt AC: Q9UT30
• Protein Name: Nucleus export protein brr6
• Gene Name: brr6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 297
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus membrane; Multi-pass membrane protein.
• Protein Description: Involved in mRNA and protein export from nucleus..
• Protein Sequence: MEMYVEDVPMPDIGPDSVLNTPIRPKYEILKSKKKTQNENDPEPMDISMSPDEKNLKKSTVRRKLRKSKPNSSSNQVSSRTRALTKRSNSSNAIIKANNQDSVYVSDWTNVHRDIPIVVSGYLQLMFNACVASIFLYFLFKIVFGIQNDVRNRVEYHKILQEEQAADCQREYLSINCDSPGPAIFEVCQKLKQCKMESSNNVGSTKLAALVFAEIIDAFISHISYKTMVFSLILVFGSLLTSNYAFGLYRARHSQNIHDYAANAIPAMIPSSRFLPSNLSDISNRNLIEAASQEEEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	DPEPMDISMSPDEKN CCCCCCCCCCCCHHH	14.67	25720772
50	Phosphorylation	EPMDISMSPDEKNLK CCCCCCCCCCHHHHC	23.55	25720772
90	Phosphorylation	ALTKRSNSSNAIIKA HHHHHCCCCCCEEEE	26.64	28889911
91	Phosphorylation	LTKRSNSSNAIIKAN HHHHCCCCCCEEEEC	34.23	24763107
292	Phosphorylation	RNLIEAASQEEEI-- HHHHHHHHHHCCC--	45.21	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRR6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRR6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRR6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC31_SCHPO	cdc31	genetic	22042620
CUT12_SCHPO	cut12	genetic	22042620
KMS2_SCHPO	kms2	genetic	22042620
SAD1_SCHPO	sad1	genetic	22042620
KMS1_SCHPO	kms1	genetic	22042620
APQ12_SCHPO	apq12	genetic	22042620
SAD1_SCHPO	sad1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.
PubMed: 18257517