dbPTM

KMS2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KMS2_SCHPO
UniProt AC	O43087
Protein Name	Karyogamy meiotic segregation protein 2
Gene Name	kms2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	457
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Associates with the spindle pole body (SPB).
Protein Description
Protein Sequence	MDEYIPFDDIVRQYDPDYTGKVSIQAFLEIVDDVDALRLNPEAPLLDNEQRQSAQDFIKDNSEIVVSTSEIKNLFYELTGLDPDTLPVNKLALRENGVLPRKSVAKPQKISENRIKRKDMFYQDASYITPRKGSPLSHSTPLSMFRTKNEYGSNKGFSHINKENADDSLIQQLYERIELQAAELRSKDEQVKELNARNAKLLEELDSSEEACKSCYTQAKTWEKKFREALRDSKEYAAQLQTIHEEYEQQQAHIVRMEELIHAVEKERKTETDYMKKESLSEQKERGAFMESNMILEEKVAHLQLENEQLRLFFKEKAPQPFQNHPPYQNLKITFPSPFFHIPYIPKTETLNDSQFAAGLSLLASELESQKNLLKKFENLKKKSSKDFLSPSTILSNAFSKVSLPNSLILRVLFFSLLFIIGIHIFYFLFFHVATIQQWPFLFWLPSTKFDNRWSPT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	QDFIKDNSEIVVSTS HHHHHCCCCEEEEHH	38.54	24763107
122	Phosphorylation	IKRKDMFYQDASYIT CCCCCCCCCCCHHCC	9.99	21712547
126	Phosphorylation	DMFYQDASYITPRKG CCCCCCCHHCCCCCC	25.92	24763107
127	Phosphorylation	MFYQDASYITPRKGS CCCCCCHHCCCCCCC	15.55	21712547
129	Phosphorylation	YQDASYITPRKGSPL CCCCHHCCCCCCCCC	14.60	21712547
134	Phosphorylation	YITPRKGSPLSHSTP HCCCCCCCCCCCCCC	26.21	28889911
137	Phosphorylation	PRKGSPLSHSTPLSM CCCCCCCCCCCCCHH	20.83	24763107
139	Phosphorylation	KGSPLSHSTPLSMFR CCCCCCCCCCCHHCC	28.48	21712547
140	Phosphorylation	GSPLSHSTPLSMFRT CCCCCCCCCCHHCCC	23.87	24763107
143	Phosphorylation	LSHSTPLSMFRTKNE CCCCCCCHHCCCCCC	19.65	21712547
147	Phosphorylation	TPLSMFRTKNEYGSN CCCHHCCCCCCCCCC	27.27	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KMS2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KMS2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KMS2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPIP_SCHPO	cdc25	genetic	24963130
PCP1_SCHPO	pcp1	physical	24963130
CUT12_SCHPO	cut12	physical	24963130
PCP1_SCHPO	pcp1	genetic	24963130
TBB_SCHPO	nda3	genetic	24963130
PLO1_SCHPO	plo1	physical	24963130
KLP5_SCHPO	klp5	physical	24963130
STU1_SCHPO	peg1	physical	24963130
ALP6_SCHPO	alp6	physical	24963130
ASE1_SCHPO	ase1	physical	24963130

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KMS2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134, AND MASSSPECTROMETRY.	18257517 [Abstract]