ALP6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALP6_SCHPO
• UniProt AC: Q9USQ2
• Protein Name: Spindle pole body component alp6
• Gene Name: alp6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 832
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Localizes to the SPB and also to the equatorial MTOC.
• Protein Description: Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles..
• Protein Sequence: MSEIHVKTALSRLADKYLQNSKNPSVPYTIETIVSFFQEIIHSISPDTFQLDIDDILYKIYSKIPPEENNDALFSKLSNLVSRLKSQTVIHNKSQILYFLYLLSPISQSSRDVSSHLLDESISNPINIPSTEVESSNFGQTRYDQVPENPQITDWDEGLENESSISIAHDSSRLNRSTETSSVQHTLITEADLLSSISYVLQGISTEYVQFKNELALLSKRIPVQYLLQMRALSETGLLYQELKVFSNYDPSVSQSIDGDNVSKAFINDQSLALQSLKSVISKELTNFLALIASLDSQIRADASLEKPMVTIRRCIAWTQVAKLKLRILSSVVNDNMNQENKKRLIQVVSKYNVHGDPLIQELSDKILTEITGPLYEMIENWIYKGELVDPYQEFFVKEKNGSESHDHQGQGDVVWKGKYFLDKELIPSFLSEELVDKIFLIGKSLNFARYGCGDFDWAQEHYQKLVKKLSYRDPHSLETVVDKAYTESINHLVYLMEEVFHLTDHLKAIKKYLLLGQGDFVDLLMESLGNSLDQPANTLFRHNLTASLESAIRSSNASYEPEYVLKRLDARLLELSHGETGWDVFTLEYKVDSPINVIITPYCSRQYLKIFNFLWRLKRIEFALAHSWRRVNLGERNVFRNLDYTKFEWHFVSCHLAEMIHFVCQLQYYILFEVIEISWQELQLAMEKPNATLDTYIEAHEKYVTSITHKGLLGGGKSRNEDSFLHQLHDILKVILNFHDAIELLYNFSCSLSNRIRINVPISTDALAAQYTPIKNELSNFTEEFQVRLQKLLHGLASHKDPEMRFLSVRLNYNEFYVSHRRRHDKDVTSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
286	Phosphorylation	SVISKELTNFLALIA HHHCHHHHHHHHHHH	25.64	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALP6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALP6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALP6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALP4_SCHPO	alp4	genetic	11080156
MAD2_SCHPO	mad2	physical	16855399
ALP4_SCHPO	alp4	physical	16855399
PPC89_SCHPO	ppc89	physical	16775007
TBG_SCHPO	gtb1	physical	11080156
ALP4_SCHPO	alp4	physical	15004232
ALP6_SCHPO	alp6	physical	15004232
ALP16_SCHPO	alp16	physical	15004232
MBO1_SCHPO	mto1	physical	15004232
GFH1_SCHPO	gfh1	physical	15004232
TBG_SCHPO	gtb1	physical	15004232
MBO1_SCHPO	mto1	physical	15120067
TBG_SCHPO	gtb1	physical	12134075
MOD21_SCHPO	mod21	physical	17021256
GFH1_SCHPO	gfh1	physical	17021256
ALP16_SCHPO	alp16	genetic	12134075
GCP3_HUMAN	TUBGCP3	physical	23886939
GCP2_HUMAN	TUBGCP2	physical	23886939
ALP4_SCHPO	alp4	physical	24006493

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-286, AND MASSSPECTROMETRY.
PubMed: 18257517