ALP4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALP4_SCHPO
• UniProt AC: Q9Y705
• Protein Name: Spindle pole body component alp4
• Gene Name: alp4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 784
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Localizes to the SPB and also to the equatorial MTOC.
• Protein Description: Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. Required for correct septation..
• Protein Sequence: MVRSISSVLAKEESENGSPIPALEEGSVYHVSLKSEGVSPFSDRIQLNYLYDGKTFSDPSNLNIHQQEACLINELLNAFMGMEGVFVHLQDMKASSEFETIIMPPSFYILPGFDLGIKDIASEMLEMGSHYLSITAFIESRSHFEYGFVNHALCAALRKFVMDYVVLIMQCENQSRIDPNFSLQTLRLYTLPTSRSLRQVYLILRDLLLSMEKNASSSDDLGLSNIDDLLEQLNEGNDISHVVNATRSKKKVCKGGQVISFLTESLTKYAGDPVARKILTYLLREASRPYTKMLNEWIHLGLVNDPYDEFMIKIHKGITSMQLDEDYTDEYWEKRYVIREDQVPPQLLDLQNKVLFAGKYLNVVLECRKGVNNLASLNAKDDTQNQLLWPSTFDDDNFTLNIMNAYVYANESLLQLLQSSQSLYAHLYSLKHYFFLDQSDFFTTFLDNAQHELRKPAKYISITKLQSQLDLALRQPGTITATDPHKEYVTVEVNQTSLIDWLMHIVSISGLEEGTSSQGNEVWNESITKQADVGNETRNFESEHNRSTQGTSKVGSDKDINGFETMQLCYKVPFPLSLILSRKAIIRYQLLFRYFLLLRHVEMQLENSWVQHSKNSAWRLNSSNAKIEQWKRNSWLLRTRMLSFVQKIIYYTTSEVIETHWGKFMGELENARTVDNLMQEHIDFLDTCLKECMLTNSRLLKVQSKLLNTCAMFASYTSTFTRSLYLLENSEESFDEGRMDKMEEILRRYEDSFSRHLKSLVNACNYFASTETAALLSLVMKLTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVRSISSVLAK ----CCCCHHHHHHH	18.53	24763107
6	Phosphorylation	--MVRSISSVLAKEE --CCCCHHHHHHHHH	18.68	24763107
7	Phosphorylation	-MVRSISSVLAKEES -CCCCHHHHHHHHHC	21.34	24763107
14	Phosphorylation	SVLAKEESENGSPIP HHHHHHHCCCCCCCC	37.14	29996109
18	Phosphorylation	KEESENGSPIPALEE HHHCCCCCCCCCCCC	31.10	25720772
35	Phosphorylation	VYHVSLKSEGVSPFS EEEEEEECCCCCCCC	44.89	21712547
39	Phosphorylation	SLKSEGVSPFSDRIQ EEECCCCCCCCCEEE	30.96	28889911
42	Phosphorylation	SEGVSPFSDRIQLNY CCCCCCCCCEEEEEE	29.39	29996109
216	Phosphorylation	LSMEKNASSSDDLGL HHHHHCCCCCCCCCC	39.51	29996109
224	Phosphorylation	SSDDLGLSNIDDLLE CCCCCCCCCHHHHHH	29.91	21712547
240	Phosphorylation	LNEGNDISHVVNATR HHCCCCHHHHHHHCC	17.06	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALP4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALP4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALP4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAD2_SCHPO	mad2	genetic	11080156
TBG_SCHPO	gtb1	genetic	15280226
MAD2_SCHPO	mad2	physical	16855399
ALP6_SCHPO	alp6	physical	16855399
TBG_SCHPO	gtb1	physical	16855399
TBG_SCHPO	gtb1	physical	11080156
ALP16_SCHPO	alp16	physical	15004232
TBG_SCHPO	gtb1	physical	15004232
MBO1_SCHPO	mto1	physical	15004232
GFH1_SCHPO	gfh1	physical	15004232
PCP1_SCHPO	pcp1	physical	15004232
ALP6_SCHPO	alp6	physical	15004232
MBO1_SCHPO	mto1	physical	15120067
TBG_SCHPO	gtb1	physical	12134075
ALP16_SCHPO	alp16	physical	17021256
GFH1_SCHPO	gfh1	physical	17021256
MOD21_SCHPO	mod21	physical	17021256
ALP16_SCHPO	alp16	genetic	12134075
ALP6_SCHPO	alp6	physical	23886939
GCP3_HUMAN	TUBGCP3	physical	23886939
GCP2_HUMAN	TUBGCP2	physical	23886939

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.