EI2BA_SCHPO - dbPTM
EI2BA_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EI2BA_SCHPO
UniProt AC Q9USP0
Protein Name Translation initiation factor eIF-2B subunit alpha
Gene Name tif221
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 341
Subcellular Localization
Protein Description Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
Protein Sequence MVESDSSGIVRHSQGEFDIVQVYKKFLQDDPEITMPVAAIEALVQLLSRSQAKTISEFMDILQNGSNTLKEGVQNNISLSAGCDIFQRFVTRSLHDVGDFEQCKRHLVENGKLFIQRARACRQRIAHLGYPLIRDGSVILTHGFSRGVAAVLLAAAKRHVRFKVFVTESRPSGSGCLMTRTLKNACIPTCMVLDSAVSFTMNRVDLVLVGAEGVVENGGLINQIGTFQLAVFAKHAHKPFYAVAESHKFVRMFPLSQYDIPFSRPILEFDDPSPETVHPEPEPIPTPSDAIHNELIMNEEQIRNNPTLDVTPPEFVSGLITDLGIIDSKSGVSEELIKLYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MVESDSSGIVR
----CCCCCCCCCCC		31.2324763107
6Phosphorylation--MVESDSSGIVRHS
--CCCCCCCCCCCCC		39.4824763107
7Phosphorylation-MVESDSSGIVRHSQ
-CCCCCCCCCCCCCC		37.2121712547
13PhosphorylationSSGIVRHSQGEFDIV
CCCCCCCCCCCEEEH		29.3521712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EI2BA_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EI2BA_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EI2BA_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PROB_SCHPOSPAC17H9.13cgenetic
22681890
PDX1_SCHPOsnz1genetic
22681890
ARF6_SCHPOarf6genetic
22681890
AATC_SCHPOSPAC10F6.13cgenetic
22681890
PNG1_SCHPOSPBC1709.14genetic
22681890
YFM8_SCHPOSPAC222.08cgenetic
22681890
AATM_SCHPOSPBC725.01genetic
22681890
CYSK_SCHPOcys11genetic
22681890
GYP51_SCHPOgyp51genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EI2BA_SCHPO

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Related Literatures of Post-Translational Modification

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