| UniProt ID | CUT7_SCHPO | |
|---|---|---|
| UniProt AC | P24339 | |
| Protein Name | Kinesin-like protein cut7 | |
| Gene Name | cut7 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 1085 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. | |
| Protein Description | Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.. | |
| Protein Sequence | MAPRVAPGGSQQFLGKQGLKAKNPVSTPNSHFRSASNPRKRREPPTIDTGYPDRSDTNSPTDHALHDENETNINVVVRVRGRTDQEVRDNSSLAVSTSGAMGAELAIQSDPSSMLVTKTYAFDKVFGPEADQLMLFENSVAPMLEQVLNGYNCTIFAYGQTGTGKTYTMSGDLSDSDGILSEGAGLIPRALYQLFSSLDNSNQEYAVKCSYYELYNEEIRDLLVSEELRKPARVFEDTSRRGNVVITGIEESYIKNAGDGLRLLREGSHRRQVAATKCNDLSSRSHSIFTITLHRKVSSGMTDETNSLTINNNSDDLLRASKLHMVDLAGSENIGRSGAENKRARETGMINQSLLTLGRVINALVEKAHHIPYRESKLTRLLQDSLGGKTKTSMIVTVSSTNTNLEETISTLEYAARAKSIRNKPQNNQLVFRKVLIKDLVLDIERLKNDLNATRKKNGVYLAESTYKELMDRVQNKDLLCQEQARKLEVLDLNVKSSREQLQYVSKSNQEHKKEVEALQLQLVNSSTELESVKSENEKLKNELVLEIEKRKKYETNEAKITTVATDLSQYYRESKEYIASLYEKLDRTERNNKENENNFWNLKFNLLTMLRSFHGSFTDETNGYFTLLNDFNASMEELLNTHSNQLLISMTKITEHFQSLDEALQSARSSCAVPNSSLDLIVSELKDSKNSLLDALEHSLQDISMSSQKLGNGISSELIELQKDMKESYRQLVQELRSLYNLQHTHEESQKELMYGVRNDIDALVKTCTTSLNDADIILSDYISDQKSKFESKQQDLIANIGKIVSNFLQEQNESLYTKADILHSHLNDTNSNIRKANEIMNNRSEEFLRNAASQAEIVGANKERIQKTVENGSQLLDSKSKAIHSNSRSMYDHCLALAESQKQGVNLEVQTLDRLLQKVKEHSEDNTKEKHQQLLDLLESLVGNNDNLIDSIKTPHTELQKITDHVLKGTTSLANHTNELLGLGDESLCNLETTIEDTSLVKLETTGDTPSKRELPATPSWTRDSSLIKETTNLNLDSDKKFVRETYTSSNQTNEPDVYDKPSNSSRTSLLRSSRSAYSKMKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 771 | Phosphorylation | ALVKTCTTSLNDADI HHHHHHCCCCCHHHH | 33.10 | 27738172 | |
| 1007 | Phosphorylation | TSLVKLETTGDTPSK CCEEEEEECCCCCCC | 46.65 | 29996109 | |
| 1008 | Phosphorylation | SLVKLETTGDTPSKR CEEEEEECCCCCCCC | 24.55 | 29996109 | |
| 1011 | Phosphorylation | KLETTGDTPSKRELP EEEECCCCCCCCCCC | 30.70 | 21712547 | |
| 1013 | Phosphorylation | ETTGDTPSKRELPAT EECCCCCCCCCCCCC | 46.57 | 29996109 | |
| 1020 | Phosphorylation | SKRELPATPSWTRDS CCCCCCCCCCCCCCC | 18.86 | 21712547 | |
| 1024 | Phosphorylation | LPATPSWTRDSSLIK CCCCCCCCCCCHHCH | 29.01 | 21712547 | |
| 1027 | Phosphorylation | TPSWTRDSSLIKETT CCCCCCCCHHCHHHC | 24.61 | 21712547 | |
| 1028 | Phosphorylation | PSWTRDSSLIKETTN CCCCCCCHHCHHHCC | 38.10 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 1011 | T | Phosphorylation | Kinase | CDC2 | P04551 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CUT7_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CUT7_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KLP2_SCHPO | klp2 | genetic | 11694582 | |
| KLP1_SCHPO | pkl1 | genetic | 11694582 | |
| KLP1_SCHPO | pkl1 | genetic | 8898367 | |
| KLP1_SCHPO | pkl1 | genetic | 18418055 | |
| TBG_SCHPO | gtb1 | genetic | 18418055 | |
| ALP4_SCHPO | alp4 | genetic | 18418055 | |
| ALP6_SCHPO | alp6 | genetic | 18418055 | |
| AGO1_SCHPO | ago1 | physical | 19883398 | |
| DCR1_SCHPO | dcr1 | physical | 19883398 | |
| RDP1_SCHPO | rdp1 | physical | 19883398 | |
| ASK1_SCHPO | ask1 | genetic | 18818364 | |
| ALP14_SCHPO | alp14 | genetic | 18818364 | |
| MPH1L_SCHPO | mph1 | genetic | 22681890 | |
| CYB51_SCHPO | SPBC29A10.16c | genetic | 22681890 | |
| ASK1_SCHPO | ask1 | genetic | 22681890 | |
| DAD2_SCHPO | dad2 | genetic | 22681890 | |
| YCV2_SCHPO | SPCC777.02 | genetic | 22681890 | |
| KLP1_SCHPO | pkl1 | genetic | 23388459 | |
| VIP1_SCHPO | asp1 | genetic | 27697865 | |
| KLP1_SCHPO | pkl1 | genetic | 25348260 | |
| KLP1_SCHPO | pkl1 | physical | 25348260 | |
| TBG_SCHPO | gtb1 | physical | 25348260 | |
| ALP4_SCHPO | alp4 | physical | 25348260 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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