dbPTM

SGO1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SGO1_SCHPO
UniProt AC	Q9P7A0
Protein Name	Shugoshin-1
Gene Name	sgo1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	319
Subcellular Localization	Nucleus. Chromosome, centromere . Localizes to the centromere. Bub1 is required for centromeric localization (PubMed:14730319). At the onset of anaphase I, it is degraded.
Protein Description	Plays a central role in chromosome cohesion during meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting centromeric rec8 from separase degradation during anaphase I..
Protein Sequence	MNFQFINSNINNEDKLPMESLKKKFLKQNREIIKINTQLSIKIRESENEIQDLIQENFTLKSYLVKLEARFRNQSQTEDLLKNFFPEIQTIHKKISQVQSLLKIIEKKCSSDFLEANVKSQFTTCENKDSKEDYQILHNKRLEYVSFNDELKSLETGQPLYCFQDFQKKVHGPPALSEKPGKCILKDKTNAHVNKIPQDEVNYSLPQKNITIFSKELKENEFESINEGETEEEKAKTSNVCVCIPCKSAEQITDLKGQATGDSSPCDFEESQPRINGREKLRRSVKVINYAIPSLRTKLRRDFDLPSDRKRKRHPRGKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of SGO1_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SGO1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SGO1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SGO1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AD1_SCHPO	par1	physical	16541025
2AAA_SCHPO	paa1	physical	16541024
2AD1_SCHPO	par1	physical	16541024
PP2A2_SCHPO	ppa2	physical	16541024
PP2A1_SCHPO	ppa1	physical	16541024
BUB1_SCHPO	bub1	physical	14730319
SGO2_SCHPO	sgo2	genetic	14972679
MAD2_SCHPO	mad2	genetic	21423721
SPO11_SCHPO	rec12	genetic	21920317
REC8_SCHPO	rec8	genetic	21920317

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SGO1_SCHPO

Related Literatures of Post-Translational Modification