IST1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IST1_SCHPO
• UniProt AC: O74490
• Protein Name: Vacuolar protein sorting-associated protein ist1
• Gene Name: ist1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 271
• Subcellular Localization: Cytoplasm . Nucleus . Golgi apparatus . Endosome.
• Protein Description: Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole (By similarity)..
• Protein Sequence: MSRLQIQLKLAASRIEILRQKEEALAKQARRNVALGLKSYSPALAKARIEPLIMQDIYIELLELLQVDVEILANRCVVLEKRAFNDSMSFKSSLYHVMAAAPQLQIKELRFVHDFLVKLYGKEFARLSDPDLATNDTAFYQLLYPPIPKDELVEAYRKELIRTYFPNDYPKEANKDIPSSAEADTMLNLESSENREQPTSLKEENTQEDDEKVNGNLANISKRAEPQNNGSTNASSLQSSNYLPTNPTLTHSNKAPSFEELAARLDRLKHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
257	Phosphorylation	THSNKAPSFEELAAR CCCCCCCCHHHHHHH	50.58	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IST1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IST1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IST1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of IST1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.