SIF2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIF2_SCHPO
• UniProt AC: O74446
• Protein Name: Sad1-interacting factor 2
• Gene Name: sif2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 382
• Subcellular Localization: Nucleus membrane ; Single-pass membrane protein . Localized primarily along the nuclear envelope in a punctate pattern.
• Protein Description: Required for sporulation where it is believed to have a role in meiotic nuclear division..
• Protein Sequence: MSNRIGPQRSTKTAAKLRLLPSTEEFDDFRRQDTGREVYSQIPQIEGSTAKRDAEHLGKRHREFLPRVTAYCTCDTFRVDLLFKFFQSRRSSHKTRPKQFDECIYSPYSYNNEETTDLLPDTLESSRGTLNRESSQESLQSIFEESGLDRNQPLFREVFCFTYGVVVLWGYTIDEEHRFLRELGRFEIEKLKIEDMEVEEFNYYITTLYQPRIFNDFIALRDASNYMIRLSISHAIAQSVKISLFEELVNETIDATKDTPQMIAETGRVNLKREEIMMAVGQLFILRININLQGSVLDSPELMWTEPQLEPIYTAARSYLEINQRVALLNQRVEVIGDLLSMLKEQITHTHDESLEWIVVILMGLLVLIALFSIVVDWKLFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	TLESSRGTLNRESSQ HHHHCCCCCCCCCHH	21.54	25720772
134	Phosphorylation	RGTLNRESSQESLQS CCCCCCCCHHHHHHH	33.80	25720772
135	Phosphorylation	GTLNRESSQESLQSI CCCCCCCHHHHHHHH	32.96	28889911
138	Phosphorylation	NRESSQESLQSIFEE CCCCHHHHHHHHHHH	24.87	25720772
141	Phosphorylation	SSQESLQSIFEESGL CHHHHHHHHHHHHCC	34.24	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIF2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIF2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIF2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHD1_SCHPO	hos2	physical	22559741
SIF2_SCHPO	sif2	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, AND MASSSPECTROMETRY.
PubMed: 18257517