dbPTM

NCS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCS1_SCHPO
UniProt AC	Q09711
Protein Name	Calcium-binding protein NCS-1
Gene Name	ncs1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	190
Subcellular Localization	Membrane Peripheral membrane protein .
Protein Description	Negatively regulates sporulation perhaps by controlling Ca(2+)-dependent desensitization of git3..
Protein Sequence	MGKSQSKLSQDQLQDLVRSTRFDKKELQQWYKGFFKDCPSGHLNKSEFQKIYKQFFPFGDPSAFAEYVFNVFDADKNGYIDFKEFICALSVTSRGELNDKLIWAFQLYDLDNNGLISYDEMLRIVDAIYKMVGSMVKLPEDEDTPEKRVNKIFNMMDKNKDGQLTLEEFCEGSKRDPTIVSALSLYDGLV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
2	N-myristoyl glycine	------MGKSQSKLS ------CCCCHHHCC	38.02	-
2	Myristoylation	------MGKSQSKLS ------CCCCHHHCC	38.02	14722091

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NCS1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCS1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
EHS1_SCHPO	yam8	genetic	20018864
EHS1_SCHPO	yam8	physical	20018864

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCS1_SCHPO

Related Literatures of Post-Translational Modification

Myristoylation
Reference	PubMed
"Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulatessporulation and confers calcium tolerance."; Hamasaki-Katagiri N., Molchanova T., Takeda K., Ames J.B.; J. Biol. Chem. 279:12744-12754(2004). Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR, FUNCTION, SUBCELLULARLOCATION, MYRISTOYLATION AT GLY-2, CALCIUM-BINDING, AND MUTAGENESIS OFGLY-2; GLU-84; GLU-120 AND GLU-168.	14722091 [Abstract]