PUF6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PUF6_SCHPO
• UniProt AC: Q9UU76
• Protein Name: Pumilio homology domain family member 6
• Gene Name: puf6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 642
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: RNA-binding protein involved in post-transcriptional regulation..
• Protein Sequence: MAIGKRKESTEVKKKDGSMNKRVKVAKLPKKVDSFSPKKKKNTTSSGSSESDSMSQNDKKKDSSLNESEDEDFAGFGESASENDELESAESEAENDEESSSQKSNSKESHAQRKKLQKERKAMKPFADTSLKAKSLWDKLRQKTSIKAEERKTIIAELFDLIRTNVKQLVFKHDMSRVVQTCVKFGSKQQRETICAELAGSYVDLCKSPYGKYLAIKIFKYGTPKMKEVILGEMYGNVVKMIRHREAAYVVEDAFREFTNLQQQRALICEFYGPEFQVFKDRTQDIHIDKLLIDHPEKRPSIMQNLWKTIEGSIAKGSIGFTMVHRAMLEFINHADSNEAKELLNLTKELIYEFVHTRDGSQVAMKLFALANAKDRKVMLKSLRPYLIETAKDSYGHLVVVAALDCTDDTIMTGKLLQAEFEGELLKLSADKFARRILLYVLVGWEDARYFSKENRELLRSLDSLKAKTSKKDPIVRRNELKATIGPLLISLISKAAGDMIAESLASQVLVDALLYAPCEKEEAVDATLKAFDGNPEQDNHLIHQIHCSRALKTLVQNGHWSGAEKQVVKAEDDLKVASKLIVIIKKYLVEWASGDGAFVVVAVLEALSDSEKQEFLKILRKHKNQLNKSEFRGTKKLLEML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	KLPKKVDSFSPKKKK ECCCCCCCCCCCCCC	30.52	28889911
36	Phosphorylation	PKKVDSFSPKKKKNT CCCCCCCCCCCCCCC	39.50	28889911
51	Phosphorylation	TSSGSSESDSMSQND CCCCCCCCHHCCCCC	36.61	27738172
79	Phosphorylation	DFAGFGESASENDEL CCCCCCCCCCCCCHH	37.16	28889911
81	Phosphorylation	AGFGESASENDELES CCCCCCCCCCCHHHH	46.33	28889911
88	Phosphorylation	SENDELESAESEAEN CCCCHHHHHHHHHHC	50.38	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PUF6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PUF6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PUF6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELP3_SCHPO	elp3	genetic	19547744

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-36; SER-79;SER-81 AND SER-88, AND MASS SPECTROMETRY.
PubMed: 18257517