METK_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METK_SCHPO
• UniProt AC: O60198
• Protein Name: S-adenosylmethionine synthase
• Gene Name: sam1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 382
• Protein Description: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate..
• Protein Sequence: MAQTFLFTSESVGEGHPDKICDQISDAILDACLKDDPFSKVACETASKTGMVMVFGEITTRSQIDYQKVIRNTIKSIGYDDSEKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEELGAGDQGIMFGYATDETPEKLPLTILLAHKLNAAMSVARRDGSLPWLRPDTKTQVTIEYEEENGAVIPRRVDTIVVSAQHADSISTEDLRSEILEKIIKPTVPAHLLDEKTVYHIQPSGRFVVGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYAARWIAKSLVAAGLARRCLVQLSYAIGVAEPLSIFVNTYGTSSKTSAELVEIIRKNFDLRPGVLVKSLKLQTPFYLSTASYGHFTDQSKPWEQPKELKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	VIRNTIKSIGYDDSE HHHHHHHHCCCCCCC	19.86	29996109
79	Phosphorylation	NTIKSIGYDDSEKGF HHHHHCCCCCCCCCC	18.20	25720772
82	Phosphorylation	KSIGYDDSEKGFDYK HHCCCCCCCCCCCCC	38.01	25720772
101	Phosphorylation	LVAIEQQSPDIAQGL EEEEECCCCCHHHHC	25.00	29996109
110	Phosphorylation	DIAQGLHYEKALEEL CHHHHCCHHHHHHHH	24.94	29996109
234	Phosphorylation	TVYHIQPSGRFVVGG CEEEECCCCCEEECC	26.65	25720772
291	Phosphorylation	AARWIAKSLVAAGLA HHHHHHHHHHHHHHH	21.03	25720772
328	Phosphorylation	TYGTSSKTSAELVEI CCCCCCCCHHHHHHH	34.81	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METK_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METK_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METK_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRD1_SCHPO	nrd1	genetic	15277777
MSA1_SCHPO	msa1	genetic	15277777
METK_SCHPO	sam1	physical	23695164
METK_SCHPO	sam1	physical	26771498
YGL4_SCHPO	mxr2	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.