dbPTM

TPIS_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPIS_SCHPO
UniProt AC	P07669
Protein Name	Triosephosphate isomerase
Gene Name	tpi1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	249
Subcellular Localization
Protein Description
Protein Sequence	MARKFFVGGNFKMNGSLESMKTIIEGLNTTKLNVGDVETVIFPQNMYLITTRQQVKKDIGVGAQNVFDKKNGAYTGENSAQSLIDAGITYTLTGHSERRTIFKESDEFVADKTKFALEQGLTVVACIGETLAEREANETINVVVRQLNAIADKVQNWSKIVIAYEPVWAIGTGKTATPEQAQEVHAEIRKWATNKLGASVAEGLRVIYGGSVNGGNCKEFLKFHDIDGFLVGGASLKPEFHNIVNVHSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	GNFKMNGSLESMKTI CCCEECCCHHHHHHH	24.78	28889911
19	Phosphorylation	KMNGSLESMKTIIEG EECCCHHHHHHHHHC	30.76	21712547
22	Phosphorylation	GSLESMKTIIEGLNT CCHHHHHHHHHCCCC	20.67	25720772
79	Phosphorylation	GAYTGENSAQSLIDA CCCCCCCHHHHHHHC	24.31	29996109
82	Phosphorylation	TGENSAQSLIDAGIT CCCCHHHHHHHCCCE	27.32	25720772
105	Phosphorylation	RRTIFKESDEFVADK CEEEECCCCCHHHHH	42.93	28889911
199	Phosphorylation	ATNKLGASVAEGLRV HHHHHCCHHHCCCEE	21.77	28889911
211	Phosphorylation	LRVIYGGSVNGGNCK CEEEECCCCCCCCHH	14.19	25720772
248	Phosphorylation	HNIVNVHSL------ HCCCCCCCC------	31.34	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TPIS_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPIS_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPIS_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TPIS_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPIS_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105 AND SER-199, ANDMASS SPECTROMETRY.	18257517 [Abstract]