ALG11_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG11_SCHPO
• UniProt AC: O74878
• Protein Name: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
• Gene Name: alg11
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 471
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
• Protein Description: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum..
• Protein Sequence: MITTLAIALFIAVVAIHSHIRRKICKEIGIRLIKKIAPVKASLYKQVGVEPKLARTVGFFHPYCNAGGGGERVLWTAVKSVQTEFPNVISVVYTGDNVSKAEILRRVKNTFEIDLDSSKIVFVYLKLRFLVSATTWHRFTLLGQSLGSMILGFEAIYRFAPDIFIDTMGYAFTFCVVKSFQNIPVGAYVHYPTISTDMLKSLKQVSLLAKVKMAYWRWFAQLYSDAGSHADYVMTNSSWTRNHIASLWGKDIQLSVVFPPCNTSELEKIDINRKREPTLLYLAQYRPEKNHENVLRSFALYFEQHPDSPAKLLLVGSVRGEEDMCFVNHLKTLATELNLQSKVKFVVDAPWPKVVEYLGTCSIGVNYMWNEHFGIGVVEYMAAGLIPVVNNSGGPKFDIVIPWIGKPTGFHASTISEYAEAYHKALTLSPQEQLEMRINARSACARFGEHVFMRDFGNVFAKLLREDYSRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	VLWTAVKSVQTEFPN HHHHHHHHCCCCCCC	16.92	25720772
97	N-linked_Glycosylation	SVVYTGDNVSKAEIL EEEEECCCCCHHHHH	41.11	-
145	Phosphorylation	RFTLLGQSLGSMILG HHHHHHHHHHHHHHH	32.66	25720772
157	Phosphorylation	ILGFEAIYRFAPDIF HHHHHHHHHHCCCEE	13.51	25720772
236	N-linked_Glycosylation	HADYVMTNSSWTRNH CCCEEEECCHHHHHH	18.89	-
262	N-linked_Glycosylation	SVVFPPCNTSELEKI EEEECCCCHHHHHEE	53.03	-
390	N-linked_Glycosylation	AGLIPVVNNSGGPKF CCCCCEECCCCCCCC	36.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG11_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG11_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG11_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of ALG11_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.