KPYK_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPYK_SCHPO
• UniProt AC: Q10208
• Protein Name: Pyruvate kinase
• Gene Name: pyk1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 509
• Protein Sequence: MSSSAVSPKQWVAGLNSELDIPAVNRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLFPLAIALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVIQPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKADLRFGVKNGVDMIFASFIRRAEDVIHIREVLGEEGKNIKIICKIENQQGVNNFDSILDVTDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVSDVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFGLVRRPLECATETTAVAAIGASIESDAKAIVVLSTSGNTARLCSKYRPSIPIVMVTRCPQRARQSHLNRGVYPVIYEKEPLSDWQKDVDARVAYGCQQAYKMNILKKGDKIIVLQGAVGGKGHTSIFRLTVAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	IPAVNRRTSIICTIG CCCCCCCCEEEEEEC	22.50	29996109
29	Phosphorylation	PAVNRRTSIICTIGP CCCCCCCEEEEEECC	14.24	28889911
38	Phosphorylation	ICTIGPKSNNVETLC EEEECCCCCCHHHHH	36.45	25720772
60	Phosphorylation	NIVRMNFSHGSYEYH CEEEEECCCCCCCHH	23.18	29996109
63	Phosphorylation	RMNFSHGSYEYHQSV EEECCCCCCCHHHHH	14.90	28889911
64	Phosphorylation	MNFSHGSYEYHQSVI EECCCCCCCHHHHHH	25.71	25720772
78	Phosphorylation	IDNARKASATNPLFP HHHHHHHCCCCCHHH	38.37	29996109
80	Phosphorylation	NARKASATNPLFPLA HHHHHCCCCCHHHEE	34.57	29996109
191	Phosphorylation	KGVNLPKTDVDLPAL CCCCCCCCCCCCHHC	39.04	24763107
220	Phosphorylation	GVDMIFASFIRRAED CCHHHHHHHHHHHHH	15.51	25720772
281	Phosphorylation	LGIEIPASQVFVAQK CCCCCCHHHHHHHHH	22.86	28889911
323	Phosphorylation	RPTRAEVSDVGNAVL CCCCEEECCHHHHEE	20.34	29996109
365	Phosphorylation	TARVAEASIPYGSLY HHHHHHHCCCCCHHH	18.66	29996109
368	Phosphorylation	VAEASIPYGSLYQEM HHHHCCCCCHHHHHH	20.06	29996109
370	Phosphorylation	EASIPYGSLYQEMFG HHCCCCCHHHHHHHH	20.33	29996109
372	Phosphorylation	SIPYGSLYQEMFGLV CCCCCHHHHHHHHHH	12.25	29996109
410	Phosphorylation	AKAIVVLSTSGNTAR CCEEEEEECCCHHHH	14.66	28889911
411	Phosphorylation	KAIVVLSTSGNTARL CEEEEEECCCHHHHH	36.17	29996109
412	Phosphorylation	AIVVLSTSGNTARLC EEEEEECCCHHHHHH	27.03	28889911
415	Phosphorylation	VLSTSGNTARLCSKY EEECCCHHHHHHHHC	19.38	28889911
458	Phosphorylation	IYEKEPLSDWQKDVD EEECCCCCHHHCCHH	47.74	28889911
470	Phosphorylation	DVDARVAYGCQQAYK CHHHHHHHHCHHHHH	18.64	25720772
500	Phosphorylation	AVGGKGHTSIFRLTV CCCCCCCCEEEEEEE	31.99	29996109
501	Phosphorylation	VGGKGHTSIFRLTVA CCCCCCCEEEEEEEC	17.66	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPYK_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPYK_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPYK_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of KPYK_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-63; SER-281 ANDSER-412, AND MASS SPECTROMETRY.
PubMed: 18257517