ACL1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACL1_SCHPO
• UniProt AC: Q9P7W3
• Protein Name: Probable ATP-citrate synthase subunit 1
• Gene Name: SPBC1703.07
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 615
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols..
• Protein Sequence: MAGSVDKPSYELFSKDTRAFVYGMQTKAVQGMLDFDYMCGRTVPSVAAIIYTFGSQSISKLYWGTKEILLPVYRTIEEACTKHPEVDVVVNFASSRSAYASTMELMEFPQIRCIAIIAEGVPERRAREILVTSKEKNVVIIGPATVGGIKPGCFKIGNTGGMMDNIVASKLYRPGSVAYVSKSGGMSNELNNIISHTTDGVYEGIAIGGDRYPGTTFIDHLIRFEADPACKLMVLLGEVGGVEEYRVIEAVKNGTIKKPIVAWAIGTCSSMFKTEVQFGHAGSFANSELETAVAKNQAMREAGIYVPETFEKLPALLQEVYEGLVKKGVIVPQPEVAPPNIPLDYAWAKELGLVRKPSSFICTISNDRGSELTYNNVPISKVFEEELGIGGVISLLWLRRRLPSYATKFLEMVLQLTADHGPCVSGAMNTIITTRAGKDLISSLVAGLLTIGTRFGGALDGAAQEFSKAYDAGLSPRAFVDSCRKANKLIPGIGHRIKSRNNPDLRVELVKGYVKKNFPSTKLLDYALAVENVTTSKKDNLILNVDGCIAVCFVDLLRNCGAFTLEEANEYINLGILNGMFVLGRSIGLIGHHLDQKRLRAPLYRHPWDDFLYLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAGSVDKPSYE ----CCCCCCCCCCC	20.01	24763107
9	Phosphorylation	AGSVDKPSYELFSKD CCCCCCCCCCCCCCC	36.66	29996109
99	Phosphorylation	FASSRSAYASTMELM ECCCHHHCCHHHHHH	11.44	25720772
358	Phosphorylation	LGLVRKPSSFICTIS HCCCCCCCCEEEEEE	40.70	28889911
359	Phosphorylation	GLVRKPSSFICTISN CCCCCCCCEEEEEEC	27.45	28889911
370	Phosphorylation	TISNDRGSELTYNNV EEECCCCCCEEECCC	30.26	25720772
615	Phosphorylation	WDDFLYLS------- CCCCCCCC-------	25.31	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACL1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACL1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACL1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of ACL1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, AND MASSSPECTROMETRY.
PubMed: 18257517