dbPTM

VATB_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VATB_SCHPO
UniProt AC	P31411
Protein Name	V-type proton ATPase subunit B
Gene Name	vma2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	503
Subcellular Localization
Protein Description	Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
Protein Sequence	MASLFDINAAAAVKDYSIKPRLSYNTVNSITGPLVILDNIRRPQYNEIVNLNLPDGSVRSGQVLEVAGHKAIVQVFEGTSGVDVRKTTIDFTGHSMRIPVSEDMLGRVFNGSGLPIDKGPNLLAEDYLDINGSPINPYARIYPEEMIQTGISSIDGLNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPTKDVHDGHEDNFSIVFAAMGVNLETARFFQRDFEENGSFERVTLFLNLANDPTIERIITPRLALSASEFLAYQTEKHVLTILTDMTSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRQLHNNAIYPPINVLPSLSRLMKSAIGEGMTRNDHGDVSNQLYAMYAIGRDAASMKSVVGEEALSQEDRLALEFLGKFEKTFISQGAYENRTIFETLDLAWSLLRIFPREMLTRIPKKILDQYYSRSSAYTESSKDVIDNTPESS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	GVDVRKTTIDFTGHS CCEEEEEEEECCCCC	22.91	28889911
95	Phosphorylation	TIDFTGHSMRIPVSE EEECCCCCCEEECCH	15.88	28889911
481	Phosphorylation	PKKILDQYYSRSSAY CHHHHHHHHHCCCCC	11.77	24763107
483	Phosphorylation	KILDQYYSRSSAYTE HHHHHHHHCCCCCCC	22.28	21712547
485	Phosphorylation	LDQYYSRSSAYTESS HHHHHHCCCCCCCCC	17.24	25720772
486	Phosphorylation	DQYYSRSSAYTESSK HHHHHCCCCCCCCCC	24.96	21712547
488	Phosphorylation	YYSRSSAYTESSKDV HHHCCCCCCCCCCHH	17.00	21712547
489	Phosphorylation	YSRSSAYTESSKDVI HHCCCCCCCCCCHHH	29.16	25720772
491	Phosphorylation	RSSAYTESSKDVIDN CCCCCCCCCCHHHCC	34.58	28889911
492	Phosphorylation	SSAYTESSKDVIDNT CCCCCCCCCHHHCCC	27.00	28889911
499	Phosphorylation	SKDVIDNTPESS--- CCHHHCCCCCCC---	25.37	21712547
502	Phosphorylation	VIDNTPESS------ HHCCCCCCC------	42.42	28889911
503	Phosphorylation	IDNTPESS------- HCCCCCCC-------	42.45	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VATB_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VATB_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VATB_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VATB_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VATB_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491; SER-492; SER-502AND SER-503, AND MASS SPECTROMETRY.	18257517 [Abstract]