IF5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5_SCHPO
• UniProt AC: Q09689
• Protein Name: Probable eukaryotic translation initiation factor 5
• Gene Name: tif5
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 395
• Protein Description: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity)..
• Protein Sequence: MATINIRRDVKDSFYRYRMPKLQSKIEGKGNGIKTVIPNMSDIAKALGRPPLYVTKFFGFELGAQTTIIADMDRYIVNGAHDAGKLQDLLDVFIRRFVLCASCQNPETELSINKKDQTISYDCKACGYRGVIDGRHKLTGVIVKNPPAKKKSHKHKRDSPVAEEEDGAEDELTRRIRQEAAELPTAEVVNDEDWAVDTSEEAVRARVQELEGNMKDSLTLSDLRGDEEEAESSRYDQFGEWLEDNYPGVSDVEIYKKMKEENIHHKSKAIVVLVQCIITSPYVGEFEKHGALFKKLCTTDKHERALLGGFERLMENTELVHIDVVPKVLLEIYQNDLVSDDMFEKWGAKASKKYVSRETSKKIHEAAEPFLTWLAEASDESESEDEEEEEEDDDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RDVKDSFYRYRMPKL HHHHHHHHHHCCHHH	15.64	25720772
159	Phosphorylation	SHKHKRDSPVAEEED CCCCCCCCCCCCCCC	25.88	28889911
173	Phosphorylation	DGAEDELTRRIRQEA CCCHHHHHHHHHHHH	18.82	29996109
198	Phosphorylation	DEDWAVDTSEEAVRA CCCCCCCCCHHHHHH	31.29	25720772
199	Phosphorylation	EDWAVDTSEEAVRAR CCCCCCCCHHHHHHH	29.04	25720772
217	Phosphorylation	LEGNMKDSLTLSDLR HHCCCCCCEEHHHHC	20.10	29996109
219	Phosphorylation	GNMKDSLTLSDLRGD CCCCCCEEHHHHCCC	28.32	29996109
221	Phosphorylation	MKDSLTLSDLRGDEE CCCCEEHHHHCCCHH	29.39	28889911
378	Phosphorylation	LTWLAEASDESESED HHHHHHCCCCCCCCC	33.16	21712547
381	Phosphorylation	LAEASDESESEDEEE HHHCCCCCCCCCHHH	51.95	21712547
383	Phosphorylation	EASDESESEDEEEEE HCCCCCCCCCHHHHC	60.68	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAS3_SCHPO	tas3	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.