dbPTM

MPP10_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPP10_SCHPO
UniProt AC	O13910
Protein Name	U3 small nucleolar ribonucleoprotein protein mpp10
Gene Name	mpp10
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	598
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity)..
Protein Sequence	MTELINSEPTLFLFPNKEDSKQLVEKAIEVFSNIKIPSTSPIQTIVTKGLDNWQIYNQLALAAKYALDDLPQVDVENEDEEEDSITSFQDEDDETSHQELSDNSEMNNRDDADDEFLGFSGPENLEDVDESSAEDVSGDEAEIMNEEGQQIEQKKDAFGLNDGFFDIDNFNKQTLALEEEAVEEGVLGDEDDGIDLLMDPDENMEDSEDESNGPQADSIMYEDFFGPKTAAGRRELKKKKAESKRKRTSKPDFKNDVQQNVIEENNESSDNEYATFDRVKKDLFASDEEDDVSADQLSSYERDKARLTQQIRELEAENVAKKSWTMMGEATSKGRPSNSLLDVDLEFETGAKPVPVQTEETTETLEDLIKNRIISKTFDDVPKRAPVAVTEFRPSELFELNENKSQRSLAEEYEEEFLKKSNADTYKSEADKKKEKEHEEIKALFSEVSRTLDSLASWHYVPPPPESTVEIVSNAPTLAMEDVQPTAASDTMALAPQEVYKPSNENREGETITRSGIAISSTEMDHQQKQARRRRVRRKHAEKRKQMAEKRRNSGTEQVVRQLSKSNVEVIGKGGERKKVASNSNKYHPIVSSNQLKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
268	Phosphorylation	VIEENNESSDNEYAT HHHHCCCCCCCCCCC	45.15	28889911
269	Phosphorylation	IEENNESSDNEYATF HHHCCCCCCCCCCCH	37.97	28889911
273	Phosphorylation	NESSDNEYATFDRVK CCCCCCCCCCHHHHH	19.73	21712547
275	Phosphorylation	SSDNEYATFDRVKKD CCCCCCCCHHHHHHH	25.76	21712547
286	Phosphorylation	VKKDLFASDEEDDVS HHHHHCCCCCCCCCC	37.92	28889911
293	Phosphorylation	SDEEDDVSADQLSSY CCCCCCCCHHHHHHH	32.87	28889911
405	Phosphorylation	FELNENKSQRSLAEE HHCCCCHHHHHHHHH	42.27	24763107
554	Phosphorylation	MAEKRRNSGTEQVVR HHHHHHCCCHHHHHH	45.33	29996109
556	Phosphorylation	EKRRNSGTEQVVRQL HHHHCCCHHHHHHHH	24.06	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MPP10_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MPP10_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPP10_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MPP10_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPP10_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-269; SER-286AND SER-293, AND MASS SPECTROMETRY.	18257517 [Abstract]