BMS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMS1_SCHPO
• UniProt AC: O94653
• Protein Name: Ribosome biogenesis protein bms1
• Gene Name: bms1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1121
• Subcellular Localization: Nucleus, nucleolus . Cytoplasm, cytoskeleton, spindle .
• Protein Description: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus..
• Protein Sequence: MDEKKGHYAKHSGPKAEKKKLKKVSDGSASNNPKAFAVASAGRMARQAMRTADISQKKLHVPMVDRTPDEAPPPVIVAVMGPPGTGKSTLIKSLVRRYSKYTISQITGPITVVAGKKRRITFLECPNDLSSMIDVAKIADLVLLLIDANFGFEMETMEFLNILAPHGMPRIMGVLTHLDLFKKTSTLREAKKRLKHRFWTELYQGAKLFYLSGVLNGRYPDREILNLSRFISVMKFRPLRWRNQHPYLLADRMEDLTLPVDIEQNPKVGRKITLYGYLHGTNLPKHDASVHIPGVGDFVTSDVSSLEDPCPPPDADKVRRRRLSEKQKLIYGPMADIGGILFDKDRVYIEVPTSNFSKDENSEAGFGERMVMQLQEAQQPLGVDGNSGLQLFSNSDAIDTVDRESSEIDNVGRKTRRQPTGLINQELIKEDEGAFDDSDVNSADENEDVDFTGKIGAINNEDESDNEEVAFADSDSDLGGQFDDEDSNLRWKEGLASKAALAYSQSGKRRRNIQKIFYDESLSPKDAYAEYKGESAKSSESDLVVSDDEEDFFKVSKVANESISSNHEKLMESESDRLSKKWENPQLLAQLKSRFITGSLLDSIEGQEEVSQDDEEGDFEDLEDEENSSDNEMEESSGSSVTAENEESADEVDFQTEREENARKKEELRLRFEEEDRGDPEKKDVDWYTEEKEKIARQLVINREAFEDMDPESRAEIEGYRAGTYVRIVINDVPFEFVEHFDSRYPVVVGGLLPNEQRYGLVQVRIKRHRWHKKILKTNDPLIFSMGWRRFQSIPVYSISDSRTRNRMLKYTPEHMHCFGTFYGPFVAPNSGFCAVQSVANSFAKAGSFRIAATGSVLNIDQSTDIVKKLKLTGVPYKIFKNTAFIKKMFSSPLEVAKFEGANIRTVSGIRGQVKKAVDQEHGHFRATFEDKILMSDIVFLRAWYPVQVRKFCTMVTNLLETDKTEWNGMRLTGEVRHELGLKTPLRPNSQYQEIVRPSRHFNPLKVPASLQAQLPFNSRQKALRPRSKPTYMQKRTVLLNAEERKVRDLLQKVMTLHTDKEAKRKAKKAAEHERYHKRMQKEEQAYIEKKREEKAEWFAQHGKRLRQDGNSSGSGKRSKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
362	Phosphorylation	NFSKDENSEAGFGER CCCCCCCCCCCHHHH	27.12	25720772
438	Phosphorylation	DEGAFDDSDVNSADE CCCCCCCCCCCCCCC	45.35	28889911
442	Phosphorylation	FDDSDVNSADENEDV CCCCCCCCCCCCCCC	36.62	28889911
464	Phosphorylation	AINNEDESDNEEVAF CCCCCCCCCCCCEEE	59.04	28889911
474	Phosphorylation	EEVAFADSDSDLGGQ CCEEECCCCCCCCCC	35.27	28889911
476	Phosphorylation	VAFADSDSDLGGQFD EEECCCCCCCCCCCC	38.39	28889911
523	Phosphorylation	IFYDESLSPKDAYAE HCCCCCCCHHHHHHH	38.90	28889911
538	Phosphorylation	YKGESAKSSESDLVV HCCCCCCCCCCCEEE	38.77	25720772
541	Phosphorylation	ESAKSSESDLVVSDD CCCCCCCCCEEECCC	37.89	21712547
546	Phosphorylation	SESDLVVSDDEEDFF CCCCEEECCCHHHHH	31.68	28889911
562	Phosphorylation	VSKVANESISSNHEK HHHHHHHHHCCCHHH	27.81	21712547
564	Phosphorylation	KVANESISSNHEKLM HHHHHHHCCCHHHHH	34.07	21712547
565	Phosphorylation	VANESISSNHEKLME HHHHHHCCCHHHHHH	40.30	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BMS1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMS1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of BMS1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; SER-442; SER-464;SER-474; SER-476 AND SER-546, AND MASS SPECTROMETRY.
PubMed: 18257517