VGL1_SCHPO - dbPTM
VGL1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VGL1_SCHPO
UniProt AC O59810
Protein Name Vigilin 1
Gene Name vgl1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1291
Subcellular Localization Endoplasmic reticulum. Cytoplasm. Under thermal stress, relocalizes from the ER to cytoplasmic foci that are distinct from P-bodies but contain stress granule markers.
Protein Description Required for cell survival under thermal stress..
Protein Sequence MEHLSNLEQPTTMDSYDFQKLTNDENLQGTESQVPSGSKSASTNGLLSAASSAAGSSFGLTPSAILQQKHENAQQGKKQNNSKSFSKKPAIDVHSEDAFPTLLSKTGPSKPRIVSWVRKTASNTSVAGSDSVSRDKIPFSASSRASSTKSTLSSVKETDFVTETLILSPDNQAPRMSFVGKPNSVAEIVRTVMHQTSTRINVSTASKTKNTTFLIQGKTSAVKAARRQILKLIGRRETKTMPCPVFVVGAIIGTNGQNLKSIMDRTSTRIQIPKRNNTANESSDDAKKPEKEENSAASTLDDLEPQYEMTTITIEGDFEGVELAQKDIEAIINERTSNTTVRISHISTELYSLLRGPDGKNIKELEEGRDLKVQIPFAYLDPSAPVNPIVLSGEKSAVRECALYLQGQAEELLRTTIPTMLPIPRRQHRFINGEKGVGIQDILRKSGCSVILPPINGDSDVVSVRGPALNISEGIRLTLERANSTIVDAVNITTAYASSKNPFDIASIVARLFLRSRKLIPLEEECAVQYHLPKREELQSNSNKTVIIEISGKSQEAVREGRAKLLALVNQFPESKFYKVTIDPLLQRYVIGSKGKNLQKLRNEHQVELLVGEYGEEDPDVIVCYIGADDGKSPDQIQKELADLAESVKSSAEASAKIVSEIIQVPSVYHKHIVGPKGTTLNAIIGKSEENVIVQLGKVSYRPDSTDDDVYIRGFSKDVERVVSEIKQVVRDAKNHEILHSHVEEFDFPAQYSKNVIGKNGSNVSSLREDLGVQINVEEGHIRIQGIKKNVEETAARIKSQIEALIDDTILRVNIPNDFHRQLIGSNGKYVRRLEEKFSVRVRFPREDDSSNSTGNELMKPTSPDEVVIRGGKKSVAAAKQELLELYEYEKSIAYTSTIDIPSKAVSRVVGRNGSTVENIRTQFDVKIDIGDVSTEETTPVSVRGAKADVENAIKEISAIAEEVKNLVEKVIKIDREYHRYLIGPNGSKLQNTIKECGGSTDKTETARLISFSNGNSEEERNSVVLRGDKEIVEALETRLLEIVEELKNQVEEKIEVPQRCISSIIGRMGSTRRDIERKTSTMLNIPNVLDPEETVTITIVGSPENCEKAKEMIQEKVASQYTQMITVPDTVYESIMKGILMKKLRSDLKVFVDTPEIKPVQPTEVVLEDHEDGVFPWKLVTHDYTGSSSSEWAVRGHKENVEKAIASLEKSIKQVMENCIAYLGIPTNLHRRIIGSGGSIINKIRKIAQVKIDVPRTPGDEIVVVQGSRAGVVKAKDLIFERLQENQNQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationPSGSKSASTNGLLSA
CCCCCCCCCCCHHHH		29.5127738172
95PhosphorylationKPAIDVHSEDAFPTL
CCCEEECCCCCHHHH		36.7024763107
115PhosphorylationPSKPRIVSWVRKTAS
CCCCCEEEEEECCCC		19.9228889911
120PhosphorylationIVSWVRKTASNTSVA
EEEEEECCCCCCCCC		25.4225720772
122PhosphorylationSWVRKTASNTSVAGS
EEEECCCCCCCCCCC		45.9624763107
124PhosphorylationVRKTASNTSVAGSDS
EECCCCCCCCCCCCC		23.2929996109
125PhosphorylationRKTASNTSVAGSDSV
ECCCCCCCCCCCCCC		17.7725720772
129PhosphorylationSNTSVAGSDSVSRDK
CCCCCCCCCCCCCCC		19.5829996109
140PhosphorylationSRDKIPFSASSRASS
CCCCCCCCCCCCCCC		23.1424763107
142PhosphorylationDKIPFSASSRASSTK
CCCCCCCCCCCCCCC		21.1128889911
143PhosphorylationKIPFSASSRASSTKS
CCCCCCCCCCCCCCH		31.4225720772
146PhosphorylationFSASSRASSTKSTLS
CCCCCCCCCCCHHHH		37.1128889911
147PhosphorylationSASSRASSTKSTLSS
CCCCCCCCCCHHHHC		38.5828889911
148PhosphorylationASSRASSTKSTLSSV
CCCCCCCCCHHHHCC		26.9025720772
150PhosphorylationSRASSTKSTLSSVKE
CCCCCCCHHHHCCCC		34.3728889911
151PhosphorylationRASSTKSTLSSVKET
CCCCCCHHHHCCCCC		32.0125720772
153PhosphorylationSSTKSTLSSVKETDF
CCCCHHHHCCCCCCC		32.9225720772
154PhosphorylationSTKSTLSSVKETDFV
CCCHHHHCCCCCCCE		40.0827738172
177PhosphorylationDNQAPRMSFVGKPNS
CCCCCCCEECCCCCH		20.3325720772
282PhosphorylationRNNTANESSDDAKKP
CCCCCCCCCCCCCCH		38.5821712547
283PhosphorylationNNTANESSDDAKKPE
CCCCCCCCCCCCCHH		33.0724763107
484PhosphorylationLTLERANSTIVDAVN
HHHHHCCCCEEEEEE		20.6528889911
485PhosphorylationTLERANSTIVDAVNI
HHHHCCCCEEEEEEE		25.4825720772
934PhosphorylationKIDIGDVSTEETTPV
EEEECCCCCCCCCCC		34.5428889911
935PhosphorylationIDIGDVSTEETTPVS
EEECCCCCCCCCCCE		37.3828889911
939PhosphorylationDVSTEETTPVSVRGA
CCCCCCCCCCEECCC		25.6028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VGL1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VGL1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VGL1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of VGL1_SCHPO !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VGL1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115; SER-934 ANDTHR-935, AND MASS SPECTROMETRY.

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