SKB15_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SKB15_SCHPO
• UniProt AC: O74453
• Protein Name: Shk1 kinase-binding protein 15
• Gene Name: skb15
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 341
• Protein Description: Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions.; Interacts with pak1/shk1..
• Protein Sequence: MLRFVVGTYTHLIYGVDADIERKKCKPLWLFEAHEGALTALAVDGIYLASTSSDETIKIFDHTRNVQIADVSVPTDIANACIRDMCFTKNHLLACHDNGQISMWSKGSWLLVHTLKSSSHKGITGIAVHPSEKLALTVGGDGKLRLWDLVRGKGGKVLPLSTIPESILFLNESSFVIMSRRGIDAFKLDLTSLFSFSSKSQLNALCLYQSKLIVGRDNGTVLVLDTSDGKILHEFTAHKKRVKSVYPVDDYLITASSDGSVCIWDKDWNLVIEHNIPEGNRITCMVAMLADSNSEPKNVEDEAAKRQSLDSETSETSSESESESEYYSTSKQPPVKRTKHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	LLVHTLKSSSHKGIT EEEEEECCCCCCCCC	39.94	25720772
118	Phosphorylation	LVHTLKSSSHKGITG EEEEECCCCCCCCCE	34.57	25720772
131	Phosphorylation	TGIAVHPSEKLALTV CEEEECCCCCEEEEE	32.27	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SKB15_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SKB15_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SKB15_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEA1_SCHPO	tea1	genetic	12764130
STE20_SCHPO	shk1	genetic	11389855

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.