HOB1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOB1_SCHPO
• UniProt AC: O74352
• Protein Name: Protein hob1
• Gene Name: hob1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 466
• Protein Description: Has a role in DNA damage signaling as a part of stress response processes..
• Protein Sequence: MSWKGFTKALARTPQTLRSKFNVGEITKDPIYEDAGRRFKSLETEAKKLAEDAKKYTDAINGLLNHQIGFADACIEIYKPISGRASDPESYEQEGNAEGIEAAEAYKEIVYDLQKNLASEMDVINTRIVNPTGELLKIVKDVDKLLLKRDHKQLDYDRHRSSFKKLQEKKDKSLKDEKKLYEAETAFEQSSQEYEYYNEMLKEELPKLFALAQSFIAPLFQGFYYMQLNVYYVLYEKMSHCEIQYFDFNTDILESYERRRGDVKDRAEALTITKFKTAKPTYKRPGMGPGGKDATASSSSSFSSKREEAAAEPSSSTATDIPPPYSTPSVAGASDYSTPSAGYQTVQTTTTTTEAAAAQYPQAAFPPPPVMPQPAAAAVTTPVAAPVAAAAAAVPVPPPAPAPAAAPAAEHVVALYDYAAQAAGDLSFHAGDRIEVVSRTDNQNEWWIGRLNGAQGQFPGNYVQLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
297	Phosphorylation	GGKDATASSSSSFSS CCCCCCCCCCCCCHH	26.80	21712547
298	Phosphorylation	GKDATASSSSSFSSK CCCCCCCCCCCCHHH	31.60	28889911
299	Phosphorylation	KDATASSSSSFSSKR CCCCCCCCCCCHHHH	27.75	28889911
300	Phosphorylation	DATASSSSSFSSKRE CCCCCCCCCCHHHHH	37.03	21712547
301	Phosphorylation	ATASSSSSFSSKREE CCCCCCCCCHHHHHH	30.97	28889911
303	Phosphorylation	ASSSSSFSSKREEAA CCCCCCCHHHHHHHH	36.58	28889911
304	Phosphorylation	SSSSSFSSKREEAAA CCCCCCHHHHHHHHC	33.45	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOB1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOB1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOB1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WEE1_SCHPO	wee1	genetic	12569356
RAD3_SCHPO	rad3	genetic	12569356
NAK1_SCHPO	nak1	genetic	15615784
NAK1_SCHPO	nak1	physical	15615784
WSP1_SCHPO	wsp1	physical	15615784
UBC2_SCHPO	rhp6	genetic	17611416
KU70_SCHPO	pku70	genetic	17671430
KU80_SCHPO	pku80	genetic	17671430
HOB3_SCHPO	hob3	genetic	12569356
ENG2_SCHPO	eng2	genetic	25040903

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-299; SER-301AND SER-303, AND MASS SPECTROMETRY.
PubMed: 18257517