WSP1_SCHPO - dbPTM
WSP1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WSP1_SCHPO
UniProt AC O36027
Protein Name Wiskott-Aldrich syndrome protein homolog 1
Gene Name wsp1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 574
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Has a role in regulating actin assembly, so regulating polarized growth..
Protein Sequence MPPSSSITQEDKATIRKYIPKSTNKIIAAAVVKLYVAYPDPNKWNYTGLCGALVLSYDTTAKCCWFKLVDVVNNSGIIWDQELYQNMDYRQDRTFFHSFELDKCLAGFSFANETDAQKFYKKVLDKGCHPESIENPVLSFITRKGSSRHAPNNSNIQPPSAAPPVPGKENYNAVGSKSPNEPELLNSLDPSLIDSLMKMGISQDQIAENADFVKAYLNESAGTPTSTSAPPIPPSIPSSRPPERVPSLSAPAPPPIPPPSNGTVSSPPNSPPRPIAPVSMNPAINSTSKPPLPPPSSRVSAAALAANKKRPPPPPPPSRRNRGKPPIGNGSSNSSLPPPPPPPRSNAAGSIPLPPQGRSAPPPPPPRSAPSTGRQPPPLSSSRAVSNPPAPPPAIPGRSAPALPPLGNASRTSTPPVPTPPSLPPSAPPSLPPSAPPSLPMGAPAAPPLPPSAPIAPPLPAGMPAAPPLPPAAPAPPPAPAPAPAAPVASIAELPQQDGRANLMASIRASGGMDLLKSRKVSASPSVASTKTSNPPVEAPPSNNLMDALASALNQRKTKVAQSDEEDEDDDEWD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPPSSSITQED
----CCCCCCCCHHH		30.7425720772
5Phosphorylation---MPPSSSITQEDK
---CCCCCCCCHHHH		31.3725720772
6Phosphorylation--MPPSSSITQEDKA
--CCCCCCCCHHHHH		33.7125720772
146PhosphorylationSFITRKGSSRHAPNN
HHHHCCCCCCCCCCC		27.5124763107
154PhosphorylationSRHAPNNSNIQPPSA
CCCCCCCCCCCCCCC		41.7821712547
160PhosphorylationNSNIQPPSAAPPVPG
CCCCCCCCCCCCCCC		43.6921712547
176PhosphorylationENYNAVGSKSPNEPE
CCCCCCCCCCCCCHH		24.3027738172
202PhosphorylationSLMKMGISQDQIAEN
HHHHCCCCHHHHHHC		23.2125720772
260PhosphorylationPPPIPPPSNGTVSSP
CCCCCCCCCCCCCCC		54.3827738172
266PhosphorylationPSNGTVSSPPNSPPR
CCCCCCCCCCCCCCC		39.7927738172
270PhosphorylationTVSSPPNSPPRPIAP
CCCCCCCCCCCCCCC		41.8927738172
279PhosphorylationPRPIAPVSMNPAINS
CCCCCCCCCCCCCCC		16.2827738172
386PhosphorylationLSSSRAVSNPPAPPP
CCCCCCCCCCCCCCC		42.5128889911
410PhosphorylationLPPLGNASRTSTPPV
CCCCCCCCCCCCCCC		39.8428889911
518PhosphorylationGGMDLLKSRKVSASP
CCHHHHHHCCCCCCC		36.9821712547
522PhosphorylationLLKSRKVSASPSVAS
HHHHCCCCCCCCCCC		26.5121712547
524PhosphorylationKSRKVSASPSVASTK
HHCCCCCCCCCCCCC		15.3624763107
526PhosphorylationRKVSASPSVASTKTS
CCCCCCCCCCCCCCC		28.0229996109
529PhosphorylationSASPSVASTKTSNPP
CCCCCCCCCCCCCCC		28.4229996109
530PhosphorylationASPSVASTKTSNPPV
CCCCCCCCCCCCCCC		28.7121712547
532PhosphorylationPSVASTKTSNPPVEA
CCCCCCCCCCCCCCC		33.5521712547
533PhosphorylationSVASTKTSNPPVEAP
CCCCCCCCCCCCCCC		49.2327738172
563PhosphorylationRKTKVAQSDEEDEDD
HCHHHCCCCCCCCCC		36.9324763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WSP1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WSP1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WSP1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NAK1_SCHPOnak1genetic
15615784
NAK1_SCHPOnak1physical
15615784
MYO1_SCHPOmyo1physical
12939254
HOB1_SCHPOhob1physical
15615784
MYO1_SCHPOmyo1physical
19805578
WSP1_SCHPOwsp1physical
19805578
YF98_SCHPOnht10physical
19805578
DIP1_SCHPOdip1genetic
21620704
BZZ1_SCHPObzz1genetic
21885283
VRP1_SCHPOvrp1physical
26771498
ACT_SCHPOact1physical
24120641
ARP3_SCHPOarp3physical
24120641
ARP2_SCHPOarp2physical
25543282
ARP3_SCHPOarp3physical
25543282
ACT_SCHPOact1physical
25543282
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WSP1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386, AND MASSSPECTROMETRY.

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