| UniProt ID | ARP3_SCHPO | |
|---|---|---|
| UniProt AC | P32390 | |
| Protein Name | Actin-related protein 3 | |
| Gene Name | act2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 427 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, actin patch. | |
| Protein Description | Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). May be involved in cytokinesis.. | |
| Protein Sequence | MASFNVPIIMDNGTGYSKLGYAGNDAPSYVFPTVIATRSAGASSGPAVSSKPSYMASKGSGHLSSKRATEDLDFFIGNDALKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHYFLLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVVDSGDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRDRNEPDSSLKTAERIKEECCYVCPDIVKEFSRFDREPDRYLKYASESITGHSTTIDVGFERFLAPEIFFNPEIASSDFLTPLPELVDNVVQSSPIDVRKGLYKNIVLSGGSTLFKNFGNRLQRDLKRIVDERIHRSEMLSGAKSGGVDVNVISHKRQRNAVWFGGSLLAQTPEFGSYCHTKADYEEYGASIARRYQIFGNSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | TRSAGASSGPAVSSK ECCCCCCCCCCCCCC | 48.54 | 27738172 | |
| 50 | Phosphorylation | SSGPAVSSKPSYMAS CCCCCCCCCCCCCCC | 41.82 | 27738172 | |
| 336 | Phosphorylation | NIVLSGGSTLFKNFG CEEECCCCHHHHHHH | 26.01 | 25720772 | |
| 369 | Phosphorylation | EMLSGAKSGGVDVNV HHHHCHHHCCCCEEE | 40.00 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARP3_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARP3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARP3_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| VIP1_SCHPO | asp1 | genetic | 10388810 | |
| ARPC1_SCHPO | arc1 | physical | 8978670 | |
| ARP2_SCHPO | arp2 | physical | 18640983 | |
| ACT_SCHPO | act1 | genetic | 8978671 | |
| GMF1_SCHPO | gmf1 | genetic | 20517925 | |
| GMFG_MOUSE | Gmfg | genetic | 20517925 | |
| AIM7_YEAST | AIM7 | genetic | 20517925 | |
| GMFB_MOUSE | Gmfb | genetic | 20517925 | |
| ARPC3_SCHPO | arc3 | physical | 21449051 | |
| ACT_SCHPO | act1 | physical | 23148219 | |
| WSP1_SCHPO | wsp1 | physical | 23148219 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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