dbPTM

DPO5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DPO5_SCHPO
UniProt AC	O60094
Protein Name	DNA polymerase V
Gene Name	pol5
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	959
Subcellular Localization	Nucleus .
Protein Description	Presumed to play a role other than chromosomal DNA replication (By similarity). Required for the control of rRNA production, via interaction with cdc10..
Protein Sequence	MATKTQLELFTKLTSNDKAIRLSSAAQLIDSLSNEEELKYSLNRLTKGLSSGRESARIGFAVALTELLTRTKDIRATHVLDLLVKHNTASGNLKGQDERDFYFGLLFGLQSIVYSGILTHKESTIEDFQRVVDLLLQLSGKKNWLQDVCFYVIYKLVEQIPEISFSSNAFLAVNKLLQTPAVSKSTEGVGLFLCLTRVPDNVKSEEVAMANWEPAHPLHKSNLVTLSKIMRQADASETGGQNSAWKQKIPMVWKYIFEEYQRKTYSGLAPFHDFWAVVVDEGIFSSTSSLERKFWGFQIMELALDYVSSDNIGDIFSKNFLHCLINHLSDEDRYLYRAAKRVTSKLEKVSKQNPTLVYPIAIHLLGERGSLNFDRVTNTKLVEHILPLADEQGILQLFQLLLSYVKRCPEDIASDTKAVEWRRQWATDTMLSILRSKRSIKQEPWVRELLEIFIAYGYFEVPESEEVIPKFSEGTQNMFRLRLMSALSYLSSSAFQQSQTDHQLGDKNWPYVALNYLLELEKSPKNNLLISMDESVIEIVQKSLSVLHKVTKKIDKKAQHLQQLNAFQLLYSLVLLQVYAGDTDSIDVLEDIDNCYSKVFNKKSKRESTSNEPTAMEILTEVMLSLLSRPSLLLRKLVDMLFTSFSEDMNRESIHLICDVLKAKESVKDSEGMFAGEEVEEDAFGETEMDEDDFEEIDTDEIEEQSDWEMISNQDASDNEELERKLDKVLEDADAKVKDEESSEEELMNDEQMLALDEKLAEVFRERKKASNKEKKKNAQETKQQIVQFKVKVIDLIDNYYKTQPNNGLGFEFLIPLLEMILKTKHKVLEEKGQAVFRNRLSKLKWTEEKPSSKNVLEALKKVHVLCGKKASLGSTGSSISQLLLKLLADTPYLKEGVEVYLKSFLLWIQEPSKSHYNANIFHDFINWGAQQRLKHQQTSTAASSPQKTGHHENEKTNH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
742	Phosphorylation	AKVKDEESSEEELMN CHHCCCCCCHHHHCC	40.79	28889911
743	Phosphorylation	KVKDEESSEEELMND HHCCCCCCHHHHCCH	52.92	28889911
939	Phosphorylation	QRLKHQQTSTAASSP HHHHHCCCCCCCCCC	22.83	21712547
940	Phosphorylation	RLKHQQTSTAASSPQ HHHHCCCCCCCCCCC	16.23	21712547
941	Phosphorylation	LKHQQTSTAASSPQK HHHCCCCCCCCCCCC	29.63	21712547
944	Phosphorylation	QQTSTAASSPQKTGH CCCCCCCCCCCCCCC	39.84	21712547
945	Phosphorylation	QTSTAASSPQKTGHH CCCCCCCCCCCCCCC	26.99	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DPO5_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DPO5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DPO5_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DPO5_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DPO5_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742 AND SER-743, ANDMASS SPECTROMETRY.	18257517 [Abstract]