MDE4_SCHPO - dbPTM
MDE4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MDE4_SCHPO
UniProt AC O43068
Protein Name Monopolin complex subunit mde4
Gene Name mde4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 421
Subcellular Localization Nucleus . Chromosome, centromere . Localizes to the central core of the centromere.
Protein Description The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules..
Protein Sequence MSTISTSTDSKLDNLGLSVTSRRNQILFYLSKALNLAHLLRSDSLQKSFLDALKQSATDSELLHKNLDEIKFLQNEKLNNEKLLEQEQNEANDYRLKVERLEHKISDYVQEINSLNSQLQIQKSNPEKHEDAVSQNRLRGSLDTVSSPSKTHKANKDEKATRLHLIIANLKKALKEKDAEVLNLQSHVSSKESELDRFKIKLETEESNWKVRLQVLESKLATQDRKLRMQKKSTERKSLLVSPRVSSPKLFSPSKQAIMGTRQPNATSGSPLSVTPFLQKTSTSIGLSSSPPQSSPSAQSSQPFSRDKYPHSMTVSPSNARYLKKHLDDTIPSNVSDINHNDHLKIPQSPSSLSPSKIPIRKKRKLKDTVSNCEFTEEDSESSFLLETIQPTKSTLRRSISPLKKRNDEINELKKGFTMKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationTISTSTDSKLDNLGL
CCCCCCCCCHHHCCE		34.9029996109
141PhosphorylationSQNRLRGSLDTVSSP
HHHHHCCCCCCCCCC		19.3529996109
146PhosphorylationRGSLDTVSSPSKTHK
CCCCCCCCCCCHHCC		38.3321712547
147PhosphorylationGSLDTVSSPSKTHKA
CCCCCCCCCCHHCCC		28.9328889911
149PhosphorylationLDTVSSPSKTHKANK
CCCCCCCCHHCCCCC		52.7329996109
238PhosphorylationKKSTERKSLLVSPRV
CCCCCCCHHCCCCCC		32.9121712547
242PhosphorylationERKSLLVSPRVSSPK
CCCHHCCCCCCCCCC		13.6324763107
246PhosphorylationLLVSPRVSSPKLFSP
HCCCCCCCCCCCCCC		42.0521712547
247PhosphorylationLVSPRVSSPKLFSPS
CCCCCCCCCCCCCCC		24.1721712547
261PhosphorylationSKQAIMGTRQPNATS
CHHHHCCCCCCCCCC		14.5724763107
267PhosphorylationGTRQPNATSGSPLSV
CCCCCCCCCCCCCCC		40.0221712547
270PhosphorylationQPNATSGSPLSVTPF
CCCCCCCCCCCCCCC		23.5721712547
273PhosphorylationATSGSPLSVTPFLQK
CCCCCCCCCCCCCCC		27.5921712547
275PhosphorylationSGSPLSVTPFLQKTS
CCCCCCCCCCCCCCC		12.6324763107
290PhosphorylationTSIGLSSSPPQSSPS
CCCCCCCCCCCCCCC		36.9027738172
312PhosphorylationSRDKYPHSMTVSPSN
CCCCCCCCEEECHHH		16.1921712547
314PhosphorylationDKYPHSMTVSPSNAR
CCCCCCEEECHHHHH		22.3521712547
316PhosphorylationYPHSMTVSPSNARYL
CCCCEEECHHHHHHH		17.2821712547
318PhosphorylationHSMTVSPSNARYLKK
CCEEECHHHHHHHHH		35.3029996109
349PhosphorylationDHLKIPQSPSSLSPS
CCCCCCCCCCCCCCC		22.7628889911
351PhosphorylationLKIPQSPSSLSPSKI
CCCCCCCCCCCCCCC		49.5129996109
352PhosphorylationKIPQSPSSLSPSKIP
CCCCCCCCCCCCCCC		35.9321712547
354PhosphorylationPQSPSSLSPSKIPIR
CCCCCCCCCCCCCCC		29.1324763107
356PhosphorylationSPSSLSPSKIPIRKK
CCCCCCCCCCCCCCC		39.5825720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MDE4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MDE4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MDE4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FLP1_SCHPOclp1physical
19523829
BUB1_SCHPObub1genetic
19523829
MAD1_SCHPOmad1genetic
19523829
MAD2_SCHPOmad2genetic
19523829
MAD3_SCHPOmad3genetic
19523829
CND2_SCHPOcnd2physical
21633354
CND1_SCHPOcnd1physical
21633354
BIR1_SCHPObir1genetic
22264609
PIC1_SCHPOpic1genetic
22264609
ARK1_SCHPOark1genetic
22264609
FLP1_SCHPOclp1genetic
22264609
CG23_SCHPOcdc13genetic
22264609
CUT7_SCHPOcut7genetic
22264609
KLP9_SCHPOklp9genetic
22264609
SWI6_SCHPOswi6genetic
22264609
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MDE4_SCHPO

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Related Literatures of Post-Translational Modification

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