dbPTM

CND1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CND1_SCHPO
UniProt AC	O94679
Protein Name	Condensin complex subunit 1
Gene Name	cnd1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1158
Subcellular Localization	Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromos
Protein Description	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase..
Protein Sequence	MSLDLLSRLKKYIHDEENSDLDSIYAECENAGLTAVVNDVIDTLLLGTSSCFDEDCLEKLFAICSHFADLSSSVRNKVYDLLTSNISSESAILEDMISANATDFTVPQTNLETTGIAFQLTVNSLSSSNQLSVIRSSTNTVKGRKKNPTTNSNWNGISHVNALLDAIITLFQKKLSRVWTTSSERDMFLSLFLKPIYTLMESEINIKNASFRSRLFNIIGLAVQFHNHTTAAETNIIQNLQYFEHLSEYAADLVHIVTVQFNSVTLAEGIIRTLCSLEFNDNDVKGPKQVALFLVRLSSLIPNLCLKQLTQLVKLLDSESYTLRCAIIEVLANVVIDQIHDEAQNEMSESVPATVQSLMDLLSERLLDISPYCRTKVLHVFIKIFDLPIKYPRKRQEIAELVIRCLQDRSSHVRRNAIKLFSKLLTTHPFSVMHNGLLTRNIWEKGLSIIEEQLNSLQPKQQEKVVDSELEVDENLLEDATMIQDDESHEGESHLENSLSEYVDSVPAEEIVKVNLTKRFYLEALQYIDIVEAGAKIISQLLFAKNKSEVIESMDFFVFCNSFGISSSKLYIKKMIHLIWVKGTSDEGNNIQNHVLSCYKTLFFEPPPNSGTNEAANYIARNLISLTYDASLAELTSLEQMLCILMKDGYFSHLVITKLWQVYSYQKKDISRTQRRGSIIVIGMLALGNTDVVMQGLDHLIQIGLGPPGLEDLVLARYTCIAIKRIGKDASGSSNINFPNSHTLCQKLCMLLLRPSFSEEWFGLEEQAIEAIYAVAKHPDELCTNIILLLTKQLFKPSNHENTTSNDDHAMDEDLDDSPEEETLKDEEEIGIRLAHLIFLVGHVAIKQLVYIEYCEAEFKRRKADAERLAVQNSNNPINGQETSEYDLITGTSEDDFSEAMTFIRERELLYGENSLLSRFAPLVVELCSNHKSHNNQSLLLAASLTLSKFMCLSNNFCMEHLPLLITILEKCDNPIIRNNLVIGLADLTVCFNHFIDEISEYLYRRLMDEESSVKKTCFMTLAFLILAGQIKVKGQLGIMARSLEDEDARISDLARMFFTDFAAKDNSVYNNFIDIFSVLSRSAEEQDEDDAKFKRIIRFLTSFIEKERHTKQLAERLAARLDRCKTQRQWDHVVYALSLLPHKADNIQKLIDDGYHE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
818	Phosphorylation	MDEDLDDSPEEETLK CCCCCCCCCCHHHCC	33.60	21712547
944	Phosphorylation	QSLLLAASLTLSKFM HHHHHHHHHHHHHHH	19.11	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CND1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CND1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CND1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAS3_SCHPO	tas3	physical	26771498
CND2_SCHPO	cnd2	physical	26771498
CND2_SCHPO	cnd2	physical	26257282
SMC2_SCHPO	cut14	genetic	25764183
SMC4_SCHPO	cut3	genetic	25764183

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CND1_SCHPO

Related Literatures of Post-Translational Modification