TIR3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIR3_YEAST
• UniProt AC: P40552
• Protein Name: Cell wall protein TIR3
• Gene Name: TIR3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 269
• Subcellular Localization: Secreted, cell wall . Membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Component of the cell wall. Required for anaerobic growth..
• Protein Sequence: MSFTKIAALLAVAAASTQLVSAEVGQYEIVEFDAILADVKANLEQYMSLAMNNPDFTLPSGVLDVYQHMTTATDDSYTSYFTEMDFAQITTAMVQVPWYSSRLEPEIIAALQSAGISITSLGQTVSESGSESATASSDASSASESSSAASSSASESSSAASSSASESSSAASSSASESSSAASSSASEAAKSSSSAKSSGSSAASSAASSASSKASSAASSSAKASSSAEKSTNSSSSATSKNAGAAMDMGFFSAGVGAAIAGAAAMLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	N-linked_Glycosylation	SSAEKSTNSSSSATS CCCCHHCCCCCCCCC	47.16	-
245	GPI-anchor	SATSKNAGAAMDMGF CCCCCCHHHCCHHCC	24.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIR3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIR3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIR3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD14_YEAST	RAD14	physical	10688190
SAC3_YEAST	SAC3	genetic	20093466
UPS1_YEAST	UPS1	genetic	20093466
TPM1_YEAST	TPM1	genetic	20093466
VPS1_YEAST	VPS1	genetic	19325107
SLX5_YEAST	SLX5	genetic	27708008
VPS17_YEAST	VPS17	genetic	27708008
PMA2_YEAST	PMA2	genetic	27708008
MED1_YEAST	MED1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.