CASP6_HUMAN - dbPTM
CASP6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CASP6_HUMAN
UniProt AC P55212
Protein Name Caspase-6
Gene Name CASP6
Organism Homo sapiens (Human).
Sequence Length 293
Subcellular Localization Cytoplasm.
Protein Description Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death..
Protein Sequence MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSASGLRR
------CCCCCCCCC		34.3127251275
2Acetylation------MSSASGLRR
------CCCCCCCCC		34.3119413330
3Phosphorylation-----MSSASGLRRG
-----CCCCCCCCCC		25.7523612710
5Phosphorylation---MSSASGLRRGHP
---CCCCCCCCCCCC		40.0627251275
9MethylationSSASGLRRGHPAGGE
CCCCCCCCCCCCCCC		53.46-
26PhosphorylationMTETDAFYKREMFDP
CCCCHHHHHHHHCCH		15.7427642862
27UbiquitinationTETDAFYKREMFDPA
CCCHHHHHHHHCCHH		35.1121963094
36AcetylationEMFDPAEKYKMDHRR
HHCCHHHHCCCCCCC		52.8825953088
36UbiquitinationEMFDPAEKYKMDHRR
HHCCHHHHCCCCCCC		52.8829967540
38AcetylationFDPAEKYKMDHRRRG
CCHHHHCCCCCCCCC		49.2525953088
38UbiquitinationFDPAEKYKMDHRRRG
CCHHHHCCCCCCCCC		49.2524816145
55 (in isoform 2)Ubiquitination-7.6821906983
55UbiquitinationLIFNHERFFWHLTLP
EEEECCEEEEEEECC		7.6822817900
58UbiquitinationNHERFFWHLTLPERR
ECCEEEEEEECCCCC		12.0922817900
65UbiquitinationHLTLPERRGTCADRD
EEECCCCCCCCCCCC		43.0129967540
79PhosphorylationDNLTRRFSDLGFEVK
CCHHHHHHHHCCEEE		30.0723927012
79O-linked_GlycosylationDNLTRRFSDLGFEVK
CCHHHHHHHHCCEEE		30.0729351928
92UbiquitinationVKCFNDLKAEELLLK
EEECCCCCHHHHHHH		57.5229967540
144UbiquitinationQTLTGLFKGDKCHSL
EECCCCCCCCCCHHH		71.8422817900
144 (in isoform 1)Ubiquitination-71.8421906983
147UbiquitinationTGLFKGDKCHSLVGK
CCCCCCCCCHHHCCC		42.3822817900
154UbiquitinationKCHSLVGKPKIFIIQ
CCHHHCCCCEEEEEE		35.3429967540
176UbiquitinationDVPVIPLDVVDNQTE
CCCEEEEECCCCCCC		32.8022505724
183UbiquitinationDVVDNQTEKLDTNIT
ECCCCCCCCCCCCCC		41.6929967540
184UbiquitinationVVDNQTEKLDTNITE
CCCCCCCCCCCCCCE		55.8629967540
257PhosphorylationTLVNRKVSQRRVDFC
HHHHHHHHHCCCCCC		22.477796396
264S-palmitoylationSQRRVDFCKDPSAIG
HHCCCCCCCCHHHCC		4.1827911442
265UbiquitinationQRRVDFCKDPSAIGK
HCCCCCCCCHHHCCC		73.0722505724
272UbiquitinationKDPSAIGKKQVPCFA
CCHHHCCCCHHHHHH		33.6429967540
273AcetylationDPSAIGKKQVPCFAS
CHHHCCCCHHHHHHH		51.847925985
273UbiquitinationDPSAIGKKQVPCFAS
CHHHCCCCHHHHHHH		51.8429967540
277S-palmitoylationIGKKQVPCFASMLTK
CCCCHHHHHHHHHHH		4.7127911442
280PhosphorylationKQVPCFASMLTKKLH
CHHHHHHHHHHHHHC		8.2828857561
284AcetylationCFASMLTKKLHFFPK
HHHHHHHHHHCCCCC		49.757925997
285UbiquitinationFASMLTKKLHFFPKS
HHHHHHHHHCCCCCC		41.79-
285AcetylationFASMLTKKLHFFPKS
HHHHHHHHHCCCCCC		41.797926009
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
257SPhosphorylationKinaseNUAK1O60285
Uniprot
257SPhosphorylationKinaseAMPK-FAMILY-GPS
257SPhosphorylationKinaseAMPK_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CASP6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CASP6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CHD3_HUMANCHD3physical
16169070
TRAF1_HUMANTRAF1physical
11098060
CASP6_HUMANCASP6physical
12232792
CASP8_HUMANCASP8physical
12232792
UBE4A_HUMANUBE4Aphysical
11802788
CSN6_HUMANCOPS6physical
17337451
SATB1_HUMANSATB1physical
18408014
SP1_HUMANSP1physical
10103059
RB_HUMANRB1physical
15735701
CASP6_HUMANCASP6physical
21988832
AAKB2_HUMANPRKAB2physical
21988832
NEMO_HUMANIKBKGphysical
21988832
CRYAB_HUMANCRYABphysical
23074197
XIAP_HUMANXIAPphysical
23074197
CASP6_HUMANCASP6physical
25416956
A4_HUMANAPPphysical
25241761
CASP3_HUMANCASP3physical
25241761
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CASP6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Regulation of caspase-6 and FLIP by the AMPK family member ARK5.";
Suzuki A., Kusakai G., Kishimoto A., Shimojo Y., Miyamoto S.,Ogura T., Ochiai A., Esumi H.;
Oncogene 23:7067-7075(2004).
Cited for: ENZYME REGULATION, PHOSPHORYLATION AT SER-257, AND MUTAGENESIS OFSER-257.

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