T23O_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T23O_HUMAN
• UniProt AC: P48775
• Protein Name: Tryptophan 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}
• Gene Name: TDO2 {ECO:0000255|HAMAP-Rule:MF_03020}
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Protein Description: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety..
• Protein Sequence: MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	KKLPVEGSEEDKSQT EECCCCCCCCHHHCC	25.06	24275569
146	Phosphorylation	DFNDFREYLSPASGF CHHHHHHHCCCCCCC	14.28	16094384
155	Phosphorylation	SPASGFQSLQFRLLE CCCCCCCHHHHHHHC	23.13	16094384
200	Phosphorylation	LKSEQEKTLLELVEA CHHHHHHHHHHHHHH	35.50	24719451
212	Phosphorylation	VEAWLERTPGLEPHG HHHHHHHCCCCCCCC	16.60	24719451
231	Phosphorylation	GKLEKNITRGLEEEF HHHHHHHCCCCHHHH	28.25	21955146
369	Phosphorylation	FVDLFNLSTYLIPRH HHHHHCCHHHHCCHH	18.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T23O_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T23O_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T23O_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASML_HUMAN	ASMTL	physical	16189514
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
ASML_HUMAN	ASMTL	physical	24722188
T23O_HUMAN	TDO2	physical	24722188
MEOX2_HUMAN	MEOX2	physical	24722188
NMNA1_HUMAN	NMNAT1	physical	24722188
REL_HUMAN	REL	physical	24722188
SDCB1_HUMAN	SDCBP	physical	24722188
T23O_HUMAN	TDO2	physical	25416956
ASML_HUMAN	ASMTL	physical	25416956
DPM1_HUMAN	DPM1	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	25416956
SDCB2_HUMAN	SDCBP2	physical	25416956
MOB1A_HUMAN	MOB1A	physical	25416956
NGB_HUMAN	NGB	physical	25416956
MOB3C_HUMAN	MOB3C	physical	25416956
ASML_HUMAN	ASMTL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00150: L-Tryptophan
• DB00779: Nalidixic Acid
• DB00500: Tolmetin

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, AND MASSSPECTROMETRY.
PubMed: 16094384