STE13_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STE13_YEAST
• UniProt AC: P33894
• Protein Name: Dipeptidyl aminopeptidase A
• Gene Name: STE13
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 931
• Subcellular Localization: Vacuole membrane; Single-pass type II membrane protein. Lysosome-like vacuoles.
• Protein Description: Responsible for the proteolytic maturation of the alpha-factor precursor..
• Protein Sequence: MSASTHSHKRKNSHLFPQRKSSNSSMDKPFFPNNDSVANTDPQSNENGHTINEIRPTEATIDVTDVPQTPFLQEQYSMRPRRESFQFNDIENQHHTHSFFSVNKFNRRWGEWSLPEKRSYVLVFTLIALSVLVLLVILIPSKLLPTKITRPKTSAGDSSLGKRSFSIENVLNGDFAIPEDTFHFIDPPQRLLGQDSDPGLYFTTKEIDGHTNFIAKQLFDETFEVNLGGNRFLYEGVEFTVSTVQINYKLDKLIFGTNLESEFRHSSKGFYWIKDLNTGNIEPILPPEKSDDNYELGLSKLSYAHFSPAYNYIYFVYENNLFLQQVNSGVAKKVTEDGSKDIFNAKPDWIYEEEVLASDQAIWWAPDDSKAVFARFNDTSVDDIRLNRYTNMNEAYLSDTKIKYPKPGFQNPQFDLFLVNLQNGIIYSINTGGQKDSILYNGKWISPDTFRFEITDRNSKILDVKVYDIPSSQMLTVRNTNSNLFNGWIEKTKDILSIPPKPELKRMDYGYIDIHADSRGFSHLFYYPTVFAKEPIQLTKGNWEVTGNGIVGYEYETDTIFFTANEIGVMSQHLYSISLTDSTTQNTFQSLQNPSDKYDFYDFELSSSARYAISKKLGPDTPIKVAGPLTRVLNVAEIHDDSILQLTKDEKFKEKIKNYDLPITSYKTMVLDDGVEINYIEIKPANLNPKKKYPILVNIYGGPGSQTFTTKSSLAFEQAVVSGLDVIVLQIEPRGTGGKGWSFRSWAREKLGYWEPRDITEVTKKFIQRNSQHIDESKIAIWGWSYGGFTSLKTVELDNGDTFKYAMAVAPVTNWTLYDSVYTERYMNQPSENHEGYFEVSTIQNFKSFESLKRLFIVHGTFDDNVHIQNTFRLVDQLNLLGLTNYDMHIFPDSDHSIRYHNAQRIVFQKLYYWLRDAFAERFDNTEVLHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSASTHSHKRK ----CCCCCCCCCCC	21.24	30377154
13	Phosphorylation	HSHKRKNSHLFPQRK CCCCCCCCCCCCCCC	25.30	21440633
21	Phosphorylation	HLFPQRKSSNSSMDK CCCCCCCCCCCCCCC	36.62	17287358
22	Phosphorylation	LFPQRKSSNSSMDKP CCCCCCCCCCCCCCC	43.71	21440633
24	Phosphorylation	PQRKSSNSSMDKPFF CCCCCCCCCCCCCCC	29.05	19823750
25	Phosphorylation	QRKSSNSSMDKPFFP CCCCCCCCCCCCCCC	34.94	24961812
153	Phosphorylation	TKITRPKTSAGDSSL CCCCCCCCCCCCCCC	26.88	27017623
154	Phosphorylation	KITRPKTSAGDSSLG CCCCCCCCCCCCCCC	36.06	27017623
377	N-linked_Glycosylation	KAVFARFNDTSVDDI CEEEEECCCCCHHHH	46.20	-
390	Phosphorylation	DIRLNRYTNMNEAYL HHHECCCCCCCHHHH	25.42	27214570
398	Phosphorylation	NMNEAYLSDTKIKYP CCCHHHHCCCCCCCC	30.47	27214570
437	Phosphorylation	NTGGQKDSILYNGKW ECCCCCCEEEECCEE	22.87	27017623
467	Phosphorylation	KILDVKVYDIPSSQM CEEEEEEEECCCHHE	11.48	19684113
471	Phosphorylation	VKVYDIPSSQMLTVR EEEEECCCHHEEEEE	33.27	28889911
472	Phosphorylation	KVYDIPSSQMLTVRN EEEECCCHHEEEEEE	17.79	28889911
814	N-linked_Glycosylation	MAVAPVTNWTLYDSV EEECCCCCCEECCCC	29.93	-
848	Phosphorylation	STIQNFKSFESLKRL EEEECCCCHHHHHEE	30.06	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STE13_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STE13_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STE13_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNX3_YEAST	SNX3	physical	17420293
SNX3_YEAST	SNX3	physical	24344282

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 17287358